Observational studyScientific reports2025
Comparison of TOF scan neuromuscular monitoring on adductor pollicis vs. corrugator supercilii and flexor hallucis brevis.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04845386 (A Comparison of Neuromuscular Transmission in the Arm and Hand Muscles With Alternative Muscles Such as the Lower Leg Muscles and the Corrugator Supercilii During General Anesthesia), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comparison of Neuromuscular Transmission in the Arm and Hand Muscles With Alternative Muscles Such as the Lower Leg Muscles and the Corrugator Supercilii During General Anesthesia
Who cites it
1 citing paper in PubMed.
- Age-Specific Pharmacology of Neuromuscular Blocking Agents: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TOF-Scan is used for neuromuscular monitoring during general anesthesia. Standard placement involves the adductor pollicis muscle, but alternative sites have been proposed for specific clinical scenarios. This study aimed to compare neuromuscular blockade parameters on the palm vs. eyelid, and the palm vs. toe. This study included cohorts A (n = 14; palm vs. eyelid) and B (n = 20; palm vs. toe). Neuromuscular blockade was induced with mivacurium, and TOF-Scan measurements were recorded until recovery. Parameters were analyzed using paired comparisons, correlations, and Bland-Altman charts. In cohort A, time to onset of neuromuscular blockade was shorter on the eyelid than on the palm (median: 60 vs. 187.5 s, p = 0.00098). Relaxation and recovery times were also shorter on the eyelid (p = 0.0023, p = 0.0064). In cohort B, time to onset was delayed on the toe compared to the palm (median: 300 vs. 195 s, p < 0.001), but relaxation and recovery times were shorter on the toe (p = 0.028, p = 0.0076). Strong correlations between measurement sites were observed, indicating reliability. TOF-Scan provides consistent results across alternative measurement sites, but site-specific differences in neuromuscular blockade dynamics reflect the varying sensitivity of these muscles to mivacurium. These findings underscore the importance of tailored neuromuscular monitoring in clinical practice.Clinical trial number NCT04845386.
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