ReviewNature reviews. Chemistry2025
Chiral medium-sized rings beyond central chirality.
Review in Nature reviews. Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Enantioselective Radical Cascade Cyclization to Axially Chiral Medium-Sized Lactones.Angewandte Chemie (International ed. in English) · 2026Article
- Atroposelective Access to π-Conjugated 1,2-Azaborepines Enabled by Palladium-Catalyzed Cyclization of N-Heterobiaryls with Alkynylboronates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Enantioselective synthesis of ring-constrained biaryls via a twist-expand-seal strategy.Nature communications · 2026Article
- Catalytic asymmetric synthesis of inherently chiral tricyclic diazepinones: Access to (+)-telenzepine.Science advances · 2026Article
- Atroposelective construction of indole-fused diazocinesChemical science · 2026Article
- Control over stereogenic centres beyond tetracoordination.Chemical science · 2026Review
- Seven-Membered Azacyclic Allenes: Synthesis, Trapping, and Stereochemical Transfer Studies.Journal of the American Chemical Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chiral medium-sized rings (MSRs), cyclic molecular structures comprising 7-11-membered rings, are prevalent in bioactive molecules owing to their unique three-dimensional structures and pharmacological properties. Compared with the extensively studied central chirality, MSRs with unconventional chirality - that is, axial chirality, inherent chirality and planar chirality - remain underexplored. The past decade has witnessed rapid advances in this field, with breakthroughs in their synthesis and applications. This Review is structured around the three underexplored types of chirality exhibited in MSRs detailing their key synthetic strategies, with a critical evaluation of their advantages and limitations. Additionally, the factors that influence the conformational stability of chiral MSRs are discussed using structure and energy analysis.
Identifiers
40659818What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.