ArticleNature medicine2025
The exposome of healthy and accelerated aging across 40 countries.
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Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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40citing papers in PubMed, 1 pooled it
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of apolipoprotein E variants on Alzheimer's disease in Latin America: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- The exposome and inflammatory bowel disease: a framework for primary and primordial prevention.Nature reviews. Gastroenterology & hepatology · 2026Review
- Work stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program.GeroScience · 2026Review
- Adverse policing as a social exposome pathway: Implications for depression, cognition, and dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures.Nature aging · 2026Article
- From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Biological aging and generational shifts in early-onset cancer risk.Nature medicine · 2026Article
- Genetic-exposome interactions and aging clocks in dementia: the ReDLat2 initiative.Nature medicine · 2026Article
- Generalizability of EEG-Based DEMENTIA Classifiers: A Multicenter study of Alzheimer's, MCI, and FTD.medRxiv : the preprint server for health sciences · 2026Article
- Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026Review
- Impact of the Early-Life Exposome on Maternal and Child Health: Considering the Perspective of Maternal-Fetal Medicine.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Elevating sleep to a global health priority: The One Sleep Health framework.Cell reports. Medicine · 2026Review
- Article
- Exposure to negative physical and social factors accelerates brain aging.Nature medicine · 2026Article
- Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- Contextualizing Blood-Based Biomarkers for Dementia Globally.Journal of neurochemistry · 2026Review
- Free-Space-Coupled Frequency-Locked Microtoroid Resonators with Reactive Polymer Functionalization for Part-Per-Trillion Gas Detection.Laser & photonics reviews · 2026Article
- Links Between Autophagy and Healthy Aging.Journal of molecular biology · 2026Review
Corrections and comments
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Authors and funding
41 authors.
Hernan Hernandez *Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0002-0597-6059
Hernando Santamaria-Garcia *PhD Program in Neuroscience, Pontificia Universidad Javeriana, Bogotá, Colombia.
Sebastian MoguilnerLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Francesca R FarinaGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
Agustina LegazLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Pavel PradoEscuela de Fonoaudiología, Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastián, Santiago de Chile, Chile.
Jhosmary CuadrosLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Liset GonzalezFacultad de Ingeniería, Universidad de Concepción, Concepción, Chile.
Raul Gonzalez-GomezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0003-2341-011X
Joaquín MigeotLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Carlos Coronel-OliverosLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Enzo TagliazucchiLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Marcelo Adrián MaitoLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
María E GodoyLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Josephine CruzatLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0002-3252-8657
Ahmed ShaheenAlexandria Faculty of Medicine, Alexandria, Egypt.
Temitope FarombiDepartment of Medicine, University College Hospital, Ibadan, Nigeria.
Daniel SalazarLondon School of Economics and Political Science, London, UK.
Lucas Uglione Da RosGraduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID http://orcid.org/0009-0000-8187-9851
Wyllians V BorelliGraduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0001-9282-0601
Eduardo R ZimmerGraduate Program in Biological Sciences: Biochemistry (PPGBioq), UFRGS, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0002-5349-0053
Alfred K NjamnshiBrain Research Africa Initiative (BRAIN), Yaounde, Cameroon.
Swati BajpaiGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
A B DeyAll India Institute of Medical Sciences, New Delhi, India.
Cyprian MostertBrain and Mind Institute, Aga Khan University, Nairobi, Kenya.
Zul MeraliBrain and Mind Institute, Aga Khan University, Nairobi, Kenya.
Mohamed SalamaGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
Sara A MoustafaGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
Sol FittipaldiLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Florencia AltschulerCognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.ORCID http://orcid.org/0000-0001-6362-963X
Vicente MedelLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
David HuepeCenter for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile.
Kristine YaffeDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Chinedu MomohBrain and Mind Institute, Aga Khan University, Nairobi, Kenya.
Harris A EyreNeuro-Policy Program, Center for Health and Biosciences, Baker Institute for Public Policy, Rice University, Houston, TX, USA.
Pawel SwiebodaInternational Center for Future Generations (ICFG), Brussels, Belgium.
Brian LawlorGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.
J Jaime MirandaSydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Claudia Duran-AniotzLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Sandra BaezGlobal Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. sandra.baez@gbhi.org.ORCID http://orcid.org/0000-0003-0875-1709
Agustin IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. agustin.ibanez@gbhi.org.ORCID http://orcid.org/0000-0001-6758-5101
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Katherine P Rankin · 2002 to 2026
$67.2MHousehold Air Pollution and Health: A Multi-Country LPG Intervention TrialUM1HL134590 · NHLBI · EMORY UNIVERSITY · PI CHECKLEY, WILLIAM, CLASEN, THOMAS F · 2016 to 2021
$31.1MLook AHEAD Sleep: Sleep-disordered breathing, circadian rest/activity rhythms, and the risk of Alzheimer's disease and related dementias in Look AHEADR01AG074562 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Adam Peter Spira, Chinedu Theresa Udeh-Momoh · 2021 to 2026
$8.8MAn automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2MUS-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1MPopulation Based Research for Alzheimer's Innovation (POP BRAIN)R35AG071916 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2021 to 2024
$3.8MSocial epigenetics of Alzheimer's disease and related dementias in Latin American countriesR01AG082056 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Michael Jay Corley · 2024 to 2026
$3.6MEvaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer DetectionR01CA241758 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALLAF, MOHAMAD, HU, JIM · 2020 to 2024
$3.1MCircadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0MLatin America Treatment & Innovation Network in Mental Health (LATIN-MH)U19MH098780 · NIMH · FUNDACAO FACULDADE DE MEDICINA · PI ARAYA, RICARDO, MENEZES, PAULO ROSSI · 2013 to 2017
$2.7MLaunching a salt substitute to reduce blood pressure at the population level-PeruU01HL114180 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2012 to 2016
$2.0MREACH-Es: Adapting a digital health tool to improve diabetes medication adherence among Latino adultsK23DK135798 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Jacqueline Anne Seiglie · 2023 to 2026
$784kFIC NIH HHS D43 TW012455FIC NIH HHS D71 TW010877FIC NIH HHS K01 TW011478FIC NIH HHS R21 TW009982FIC NIH HHS R21 TW011740NCI NIH HHS P20 CA217231NCI NIH HHS R01 CA241758NHLBI NIH HHS HHSN268200900033CNHLBI NIH HHS U01 HL114180NHLBI NIH HHS UM1 HL134590NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG074562NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG082056NIA NIH HHS R01 AG083799NIA NIH HHS R35 AG071916NIDDK NIH HHS K23 DK135798NIMH NIH HHS U19 MH098780Wellcome Trust
Abstract
Protective and risk factors can drive healthy or accelerated aging, with distinct environments modulating their effects. The impact of the exposome-the combined physical and social exposures experienced throughout life-on accelerated aging remains unknown. We assessed delayed and accelerated aging in 161,981 participants from 40 countries (45.09% female; mean age, 67.06; s.d., 9.85) by measuring biobehavioral age gaps (BBAGs), defined as the difference between estimated age from protective and risk factors and chronological age, in cross-sectional and longitudinal designs. BBAGs predicted chronological age, followed by regional and exposomal factor analyses, linked to accelerated aging. Europe led in healthy aging, while Egypt and South Africa showed the greatest acceleration; Asia and Latin America fell in between (Cliff's delta (δd) = 0.15-0.52; all P < 0.0001). Accelerated aging was more evident in eastern and southern Europe; globally, it was also associated with lower income (δd = 0.48-0.56, P < 1 × 10
Indexed as
AgingExposomeHealthy AgingAdultAgedAged, 80 and overCross-Sectional StudiesEuropeFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsSocioeconomic Factors
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