ArticleScientific reports2025
Hierarchical micro-nano topographies to control Bacteria and mesenchymal stem cells biological responses.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Antibacterial surface engineering: bioinspiration from leaves to medical devices.RSC applied interfaces · 2026Review
- Prosthetic Corneal Surgery: A Narrative Review of Current Keratoprostheses and the Future Prospects of New Biomaterials.Bioengineering (Basel, Switzerland) · 2026Review
- Heterogeneity and Clinical Relevance of Human Adipose Stromal and Progenitor Cells.Diabetes & metabolism journal · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
An ideal implant surface should promote cell attachment and tissue integration while preventing bacterial colonization. Engineering the surface topography of a biomaterial implant to elicit a differential response is a promising approach to dealing with both issues. To achieve this, we integrated Moth-Eye (ME) nanocones with micrometric features such as gratings and pillars in various hierarchical configurations, leading to different responses in bacteria and cells. These hierarchical topographies were tested on different polymers to compare their biological responses. Mesenchymal stem cells (MSCs) were employed as a model system to study cell behavior, given their ability to proliferate, self-renew, and differentiate. The bactericidal effect was tested using gram-negative Escherichia coli and gram-positive Staphylococcus aureus. Results show that these topographies-maintained cell viability and influenced cell morphology, orientation, migration and differentiation, which are crucial processes for regeneration and osseointegration. Finite Element Method (FEM) simulations estimated the traction forces generated by cells on these surfaces. Overall, the hierarchical topographies enhanced the expression of osteogenic markers in the MSCs while retaining the bactericidal properties of the ME nanostructures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.