Neutrophil to high-density lipoprotein cholesterol ratio predicts deep venous thrombosis in spontaneous intracerebral hemorrhage.

Deep vein thrombosis (DVT) is a common and serious complication of spontaneous intracerebral hemorrhage (ICH). The timely recognition and treatment of DVT can significantly mitigate several negative consequences. To investigate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and the occurrence of DVT in ICH patients. This multicenter, retrospective cohort study included patients diagnosed with ICH from three hospitals. The primary outcome was the occurrence of DVT. The NHR was calculated using complete blood counts. Receiver operating characteristic (ROC) analysis was performed to determine the optimal NHR threshold for predicting DVT and to compare its predictive performance with that of other biomarkers. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with DVT and to explore clinical complications related to NHR. A total of 5,004 patients were ultimately included in this study, among whom 359 (7.2%) were diagnosed with DVT. The optimal NHR cutoff for predicting DVT was 6.55, based on the Youden Index from the ROC curve, and was used to dichotomize the study population. In multivariable analyses, even after adjustment, a higher NHR was associated with an increased occurrence of DVT (adjusted odds ratio 1.69, 95% confidence interval 1.33-2.16) and its complications. Additionally, ROC analysis showed that NHR had superior predictive ability for DVT compared to single markers. In patients with ICH, a high NHR (≥ 6.55) independently predicts DVT and may serve as a laboratory marker for its occurrence.