Evidence map›Paper›PMID 40659715›Full record

ArticleScientific reports2025

Development of mercapto-phenyl-1,2,4-triazole bearing thio-quinoline as a novel class of tyrosinase inhibitors: an in vitro and in silico study.

Nazanin Motamedi Shakib, Mohammad Hosein Sayahi, Najmeh Oliyaei, Milad Noori, Navid Dastyafteh, Mohammad Mahdavi, Bagher Larijani, Parviz Rashidi Ranjbar, Aida Iraji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Enzymatic, cell-based, andRSC advances · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nazanin Motamedi ShakibSchool of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Mohammad Hosein SayahiDepartment of Chemistry, Payame Noor University, Tehran, Iran.
Najmeh OliyaeiStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Milad NooriEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Navid DastyaftehEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad MahdaviEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Bagher LarijaniEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Parviz Rashidi RanjbarSchool of Chemistry, College of Science, University of Tehran, Tehran, Iran. parvizrashidi2@ut.ac.ir.
Aida IrajiStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. aida.iraji@gmail.com.

Funding

Vice-Chancellor for Research, Shiraz University of Medical Sciences IR.SUMS.REC.1403.388
6 · The paper itself

Abstract

In this study, a novel series of mercapto-phenyl-1,2,4-triazole-bearing thio-quinoline moieties was designed, synthesized, and evaluated for their anti-tyrosinase activities. All compounds were tested for inhibitory activity against tyrosinase, compound 12j was found to be the most potent with IC

Indexed as

Enzyme InhibitorsMonophenol MonooxygenaseQuinolinesTriazolesAntioxidantsCatalytic DomainHydrogen BondingMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAntioxidantsEnzyme InhibitorsMonophenol MonooxygenaseQuinolinesTriazolesMolecular dockingMolecular dynamics simulationPhenyl-1,2,4-triazoleStructure–activity relationshipThio-quinolineTyrosinase inhibitors

Identifiers

PMID40659715
PMCPMC12259978

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.