ArticleNPJ Parkinson's disease2025
Fasting and postprandial Ghrelin levels in Parkinson's disease: a systematic review and meta-analysis.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.International journal of molecular sciences · 2025Review
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Authors and funding
3 authors.
Funding
Abstract
Parkinson's disease (PD) is a progressive movement disorder with motor and non-motor symptoms, including gastrointestinal and olfactory dysfunctions. These symptoms may be associated with plasma concentrations of the hormone ghrelin. Lower fasting and postprandial plasma levels of total and active ghrelin were reported in PD, despite heterogeneous findings. In this meta-analysis, we assessed the magnitude of ghrelin dysregulation in PD and explored associated factors. We included quasi-experimental and observational studies assessing fasting and postprandial plasma concentrations of total and/or active ghrelin in individuals with PD and controls (eight studies; 985 subjects). Compared to controls, fasting individuals with PD exhibited a significant reduction in total and active ghrelin concentrations. PD also showed significantly reduced postprandial concentrations of total and active ghrelin. This meta-analysis suggests that ghrelin may be crucially involved in the dysfunctions often observed in PD. Further studies should explore factors such as sex, drug therapy, and disease stages.
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Registered trials
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