Evidence map›Paper›PMID 40659624›Full record

ArticleNature communications2025

Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1

Hannes Vietzen, Laura M Kühner, Sarah M Berger, Markus Ponleitner, Marianne Graninger, Charlotte Pistorius, Christof Jungbauer, Markus Reindl, Henrieke Saucke, Franziska Kauth and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. EBNA1Neurology(R) neuroimmunology & neuroinflammation · 2026
    Article
  3. Article
  4. Review
  5. A framework for blood biomarker discovery in MS.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hannes VietzenCenter for Virology, Medical University of Vienna, Vienna, Austria. hannes.vietzen@meduniwien.ac.at.ORCID http://orcid.org/0000-0003-3993-6538
Laura M KühnerCenter for Virology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0009-0000-5830-9009
Sarah M BergerCenter for Virology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-4633-8245
Markus PonleitnerDepartment of Neurology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-3709-1845
Marianne GraningerCenter for Virology, Medical University of Vienna, Vienna, Austria.
Charlotte PistoriusAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, Vienna, Austria.
Christof JungbauerAustrian Red Cross, Blood Service for Vienna, Lower Austria and Burgenland, Vienna, Austria.ORCID http://orcid.org/0000-0002-2482-7147
Markus ReindlClinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-2817-1402
Henrieke SauckeDepartment of Pediatric Neurology, Children´s Hospital Datteln, University Witten/ Herdecke, Datteln, Germany.
Franziska KauthDepartment of Pediatric Neurology, Children´s Hospital Datteln, University Witten/ Herdecke, Datteln, Germany.
Eva-Maria WendelDivision of Pediatric Neurology, Department of Pediatrics, Olgahospital, Stuttgart, Germany.
Kevin RostásyDepartment of Pediatric Neurology, Children´s Hospital Datteln, University Witten/ Herdecke, Datteln, Germany.
Markus BreuDepartment of Neurology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-3825-5749
Barbara KornekDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Gabriel BstehDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Thomas BergerDepartment of Neurology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-5626-1144
Paulus Rommer *Department of Neurology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-5209-6647
Elisabeth Puchhammer-Stöckl *Center for Virology, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an immune-mediated demyelinating disease. Epstein-Barr virus (EBV) encodes for the EBNA-1

Indexed as

Antibodies, ViralEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensHerpesvirus 4, HumanMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingAdultBiomarkersCase-Control StudiesFemaleHumansImmunoglobulin GLongitudinal StudiesMaleMiddle AgedRisk FactorsAntibodies, ViralBiomarkersEpstein-Barr Virus Nuclear AntigensImmunoglobulin G

Identifiers

PMID40659624
PMCPMC12259891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.