Evidence map›Paper›PMID 40659623›Full record

ArticleNPJ science of food2025

Polystyrene microplastics induce potential toxicity through the gut-mammary axis.

Zhanhang Wang, Shiyu Wang, Shujuan Liu, Zhewei Wang, Fu Li, Qiqi Bu, Xiaopeng An

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhanhang WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Shiyu WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Shujuan LiuCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Zhewei WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Fu LiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Qiqi BuBioengineering College, Chongqing University, Chongqing, China.
Xiaopeng AnCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China. anxiaopengdky@163.com.

Funding

Experimental Demonstration Base of Dairy Goat in Heshui, Northwest Agriculture and Forestry University, China K4050422535Key Research and Development Projects of Shaanxi Province 2024NC-YBXM-082
6 · The paper itself

Abstract

Microplastics (MPs), as an emerging environmental pollutant, pose a grave threat to food safety and public health. However, studies on MP toxicity to organs other than the intestine remain limited, especially its link to the intestinal microbiota. To address this gap, we evaluated the potential toxicity of polystyrene (PS)-MPs to the gut and mammary glands during lactation exposure in mice. PS-MPs (~1 μm) can disrupt the intestinal barrier and cause colonic inflammation and gut microbiota dysbiosis. Moreover, they can accumulate in mammary tissue and cause inflammatory damage. Transcriptome data suggested that PS-MPs cause maternal mammary lipid metabolism disorders and ferroptosis. Fecal microbial transplant (FMT) was then performed, and it reproduced the observed leakage of the blood-milk barrier and inflammation of the mammary gland. This study demonstrated that MPs induced gut and mammary inflammation and exacerbated inflammatory damage through the gut-mammary axis. In addition, MPs caused mammary lipid disorders and ferroptosis. The findings confirmed that PS-MPs may be transported to mammalian organs other than the intestine (e.g., mammary gland) and revealed the critical role of the intestinal microbiota. These findings will provide guidance for further studies on the potential foodborne risks of MPs.

Identifiers

PMID40659623
PMCPMC12259839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.