Evidence map›Paper›PMID 40659561›Full record

ArticleJournal of microbiology and biotechnology2025

Protective Effects of Ginseng Soluble Dietary Fiber and Its Fecal Microbiota Extract on Antibiotic-Induced Gut Dysbiosis Obese Mice.

Luran Yang, Mei Hua, Da Li, Fan Li, Yuguang He, Xinyu Miao, Mubai Sun, Honghong Niu, Fenghao An, Jing Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Protective Effects ofJournal of microbiology and biotechnology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luran YangAgronomy of Food Science and Engineering, Yanbian University, Yanji 133002, Jilin, P.R. China.
Mei HuaInstitute of Agro-food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China.
Da LiInstitute of Agro-food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China.
Fan LiSchool of Life Science, Northeast Normal University, Changchun 130033, Jilin, P.R. China.
Yuguang HeInstitute of Agro-food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China.
Xinyu MiaoInstitute of Agro-food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China.
Mubai SunInstitute of Agro-food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China.
Honghong NiuInstitute of Agro-food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China.
Fenghao AnAgronomy of Food Science and Engineering, Yanbian University, Yanji 133002, Jilin, P.R. China.
Jing WangAgronomy of Food Science and Engineering, Yanbian University, Yanji 133002, Jilin, P.R. China.
Min YangAgronomy of Food Science and Engineering, Yanbian University, Yanji 133002, Jilin, P.R. China.
Jinyuan LuInstitute of Agro-food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China.
Hongyan XuAgronomy of Food Science and Engineering, Yanbian University, Yanji 133002, Jilin, P.R. China.
Jinghui WangInstitute of Agro-food Technology, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged or improper antibiotic use may increase the risk of obesity. Ginseng soluble dietary fiber (G-SDF) has been shown to inhibit obesity and promote the growth of intestinal probiotics. However, its role in antibiotic-induced gut dysbiosis obese mice (ADIO) remains unclear, and this study aimed to elucidate this role. The results indicated that G-SDF and its fecal microbiota extract (SDFfbs) significantly reduced body weight, insulin resistance, hepatic fat accumulation, abnormal blood and liver glucose-lipid metabolism, oxidative stress, and immune-inflammatory responses in ADIO mice. G-SDF and SDFfbs also inhibited the LPS/TLR4/MyD88/NF-κB signaling pathway, restored the expression of the gut barrier proteins Occludin and Claudin1, and protected against intestinal damage in ADIO mice. In particular, G-SDF and SDFfbs significantly increased the abundance of Firmicutes and Bacteroidetes and decreased the abundance of harmful

Indexed as

Anti-Bacterial AgentsDietary FiberDysbiosisGastrointestinal MicrobiomeObesityPanaxPlant ExtractsAnimalsBacteriaBody WeightDisease Models, AnimalFecesInsulin ResistanceMaleMiceMice, Inbred C57BLAnti-Bacterial AgentsDietary FiberMyeloid Differentiation Factor 88NF-kappa BPlant ExtractsTlr4 protein, mouseToll-Like Receptor 4antibiotic-induced gut dysbiosisfecal microbiota transplantationGinseng soluble dietary fiberintestinal floraLPS/TLR4/MyD88/NF-κB pathwayobese mice

Identifiers

PMID40659561
PMCPMC12283264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.