Evidence map›Paper›PMID 40659529›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance.

Hongyang Jing, Minyi Wu, Guanglin Xing, Dong Lin, Peng Chen, Lei Li, Zheng Yu, Hongsheng Zhang, Hongsheng Wang, Huabo Su and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Hongyang JingDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.ORCID 0000-0003-2811-1266
Minyi WuDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Guanglin XingDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Dong LinChinese Institutes for Medical Research, Beijing 100069, China.
Peng ChenDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Lei LiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Zheng YuDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Hongsheng ZhangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Hongsheng WangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Huabo SuVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.
Wen-Cheng XiongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Lin MeiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 linmei@cimrbj.ac.cn.ORCID 0000-0001-5772-1229

Funding

Neddylation and cardiac protein quality controlR01HL124248 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2014 to 2024
$4.1M
Mitochondrial quality control in the heartR01HL165205 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2022 to 2025
$2.4M
Elucidating the role of Cullin 3 in the heartR01HL173796 · NHLBI · AUGUSTA UNIVERSITY · PI Huabo Su · 2024 to 2026
$2.0M
Role of Neddylation in Cardiac DevelopmentF31HL139079 · NHLBI · AUGUSTA UNIVERSITY · PI LITTLEJOHN, RODNEY ERIC · 2017 to 2019
$116k
NHLBI NIH HHS F31 HL139079NHLBI NIH HHS R01 HL124248NHLBI NIH HHS R01 HL165205NHLBI NIH HHS R01 HL173796
6 · The paper itself

Abstract

Rapsyn is a scaffold protein that is thought to anchor acetylcholine receptors at the neuromuscular junction (NMJ). We showed that it may be an E3 ligase that regulates NMJ development by neddylation. To obtain genetical evidence, we mutated Nae1 (APP-BP1), an obligatory subunit of the neddylation E1 enzyme specifically in muscle cells. The mutation decreased the stability of acetylcholine receptor (AChR)α, reduced AChR clustering, and impaired NMJ development in

Indexed as

Muscle ProteinsNeuromuscular JunctionUbiquitin-Activating EnzymesAnimalsAnimals, NewbornFemaleMaleMiceMice, Inbred C57BLMice, TransgenicMutationNEDD8 ProteinReceptors, CholinergicUbiquitin-Protein LigasesMuscle ProteinsNEDD8 Proteinperipheral membrane protein 43KReceptors, CholinergicUbiquitin-Activating EnzymesUbiquitin-Protein LigasesAChRNae1neddylationneuromuscular junctionrapsyn

Identifiers

PMID40659529
PMCPMC12352533

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.