Evidence map›Paper›PMID 40659526›Full record

ArticleGenes & development2025

A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family.

Rima M Sakhawala, Reyhaneh Tirgar, Karl-Frédéric Vieux, Dustin Haskell, Guoyun Yu, Anna Zinovyeva, Katherine McJunkin

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rima M SakhawalaLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA.
Reyhaneh TirgarLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA.
Karl-Frédéric VieuxLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA.
Dustin HaskellDivision of Biology, Kansas State University, Manhattan, Kansas 66506, USA.
Guoyun YuLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA.
Anna ZinovyevaDivision of Biology, Kansas State University, Manhattan, Kansas 66506, USA.
Katherine McJunkinLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA; katherine.mcjunkin@nih.gov.ORCID 0000-0001-9730-442X

Funding

Biological functions and post-transcriptional regulation of microRNAsZIADK075147 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI MCJUNKIN, KATHERINE · 2018 to 2025
$14.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular control of microRNA gene-regulatory activity.R35GM124828 · NIGMS · KANSAS STATE UNIVERSITY · PI Anna Zinovyeva · 2017 to 2026
$3.2M
Intramural NIH HHS ZIA DK075147NIGMS NIH HHS R35 GM124828NIH HHS P40 OD010440
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are short RNAs that post-transcriptionally regulate gene expression. In canonical miRNA biogenesis, primary miRNAs are transcribed from intergenic loci or intronic regions by RNA polymerase II and sequentially cleaved by the Microprocessor complex and Dicer, and the resulting mature miRNAs are loaded into Argonaute to repress target mRNAs. A minority of miRNAs are generated via noncanonical biogenesis pathways that bypass the Microprocessor complex and/or Dicer. Here, we describe a new Pol III-dependent, Microprocessor-independent, and Dicer-dependent biogenesis pathway exemplified by the

Indexed as

Caenorhabditis elegansGerm CellsMicroRNAsRNA Polymerase IIIAnimalsCaenorhabditis elegans ProteinsRibonuclease IIICaenorhabditis elegans ProteinsMicroRNAsRibonuclease IIIRNA Polymerase IIIDGCR8DroshamiR-1277miR-153miR-32miR-33amir-8196pash-1PashaRNA polymerase III

Identifiers

PMID40659526
PMCPMC12487709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.