Trial reportBMJ paediatrics open2025
Effect of early sodium supplementation on weight gain of very preterm infants: a randomised controlled trial.
Trial report in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Changing Landscape of Sodium Needs in the Preterm Neonate for Optimizing Growth and Development.Nutrients · 2026Review
- Sodium Supplementation Algorithm to Promote Growth in Infants Who Are Preterm: Randomized Clinical Trial.Pediatrics open science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPreterm neonates are at risk of impaired growth. Hyponatraemia in preterm neonates is due to renal immaturity and can lead to growth failure. We aimed to assess the effect of early enteral sodium supplementation on weight gain velocity from birth to 34 weeks postmenstrual age in preterm neonates.
methodsIn this double-blinded randomised controlled trial, we recruited neonates born between 25 weeks and 30 weeks+6 days of gestation who received a minimum feed volume of 100 mL/kg/day before 10 days of life. In the intervention group, 4 mEq/kg/day of oral sodium was administered using 15% saline and, in the control group, normal saline was given as a placebo. The primary outcome was mean weight gain velocity in g/kg/day.
resultsA total of 104 neonates were recruited with 52 infants in each group. Mean (SD) weight gain velocity (g/kg/day) was significantly greater in intervention than in control group (18.0±4.4 vs 14.4±3.9; mean difference 3.6 with 95% CI 2.04 to 5.27, p<0.001). Linear growth (cm/week) was greater in intervention than in control group (0.88±0.18 vs 0.73±0.28 cm/week; mean difference 0.14 with 95% CI 0.05 to 0.24, p=0.04). Subgroup analysis in extreme preterm showed similar results. There was no significant difference in head growth or clinical outcomes between the groups.
conclusionEarly postnatal sodium supplementation improves in-hospital weight gain and linear growth in very preterm neonates.
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