Observational studyPediatric obesity2025
Mediating Effect of Infant Rapid Weight Gain on the Association Between Exclusive Breastfeeding and the Risk of Obesity Later in Life.
Observational study in Pediatric obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Infant hyperglycemic excursions by saliva 1,5-anhydroglucitol varied by weight status, rapid weight gain, and mode of feeding: an exploratory secondary analysis.The American journal of clinical nutrition · 2026Trial
- Mediating Effect of Infant Rapid Weight Gain on the Association Between Exclusive Breastfeeding and the Risk of Obesity Later in Life.Pediatric obesity · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionObesity is a global health problem, with an impact on future health. Early factors such as infant feeding and rapid weight gain (RWG) may play a role in its development. However, their contribution is not fully understood.
objectiveTo analyse associations and potential interactions between the type of infant feeding during the first 4 months of age, RWG and later development of obesity in children at 6 years of age. MATERIALS AND
methodsThis observational longitudinal study examines growth in 834 children born at term with adequate weight for their gestational age. Data were collected from birth to 6 years, focusing on weight, height and body mass index (BMI) z-scores. The relationships between infant feeding, RWG, and BMI at 6 years were explored using mediation models.
resultsFormula-fed infants showed higher BMI z-scores and obesity prevalence at 6 years compared to exclusively breastfed infants (p = 0.012 and p = 0.003 respectively). RWG also was associated with higher BMI z-scores and obesity (p < 0.001 in both cases), with formula-fed infants more likely to experience RWG (39.7% vs. 32.2%; p = 0.036). Mediation analysis revealed that the association between feeding type and BMI at 6 years is partly positively mediated by infant RWG up to 6 months.
conclusionsInfant feeding practices, particularly exclusive breastfeeding in the first 4 months, are associated with weight and BMI trajectories up to 6 years. Rapid weight gain mediates this relationship in the first 6 months, but from 6 to 12 months.
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