Evidence map›Paper›PMID 40659335›Full record

ArticleCellular reprogramming2025

Transformation of an Olfactory Placode-Derived Cell into One with Stem Cell Characteristics by Disrupting Epigenetic Barriers.

Ghazia Abbas, Rutesh Vyas, Joyce C Noble, Brian Lin, Robert P Lane

Abstract read
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In one paragraph

Article in Cellular reprogramming, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Ghazia AbbasDepartment of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut, USA.
Rutesh VyasDepartment of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut, USA.
Joyce C NobleDepartment of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut, USA.
Brian LinDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Robert P LaneDepartment of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut, USA.

Funding

Pheromone Receptor Genomic Evolution and Gene RegulationR01DC006267 · NIDCD · WESLEYAN UNIVERSITY · PI LANE, ROBERT P. · 2003 to 2014
$3.6M
NIDCD NIH HHS R01 DC006267
6 · The paper itself

Abstract

The mammalian olfactory neuronal lineage is regenerative, and accordingly, maintains a population of pluripotent cells that replenish olfactory sensory neurons and other olfactory cell types during the life of the animal. Moreover, in response to acute injury, the early transit amplifying cells along the olfactory sensory neuronal lineage are able to de-differentiate to shift resources in support of tissue restoration. In order to further explore plasticity of various cellular stages along the olfactory sensory neuronal lineage, we challenged the epigenetic stability of olfactory placode-derived cell lines that model immature olfactory sensory neuronal stages. We found that perturbation of the

Indexed as

Cellular ReprogrammingEpigenesis, GeneticOlfactory MucosaOlfactory Receptor NeuronsAnimalsCell DifferentiationCell LineageEctodermal PlacodesHistone-Lysine N-MethyltransferaseMiceSOXB1 Transcription FactorsHistone-Lysine N-MethyltransferaseSox2 protein, mouseSOXB1 Transcription Factorschromatindifferentiationepigeneticsolfactoryplasticityreprogramming

Identifiers

PMID40659335
PMCPMC13622967

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.