Evidence map›Paper›PMID 40659090›Full record

ReviewCurrent opinion in insect science2025

Endosymbionts interacting with sex-determining genes and processes.

Laura C Fricke, Matthew D Villalta, Amelia Ri Lindsey

Abstract readReview
In one paragraph

Review in Current opinion in insect science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Applied and environmental microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laura C FrickeDepartment of Entomology, University of Minnesota, 1980 Folwell Ave, St Paul, MN 55108, USA.
Matthew D VillaltaDepartment of Entomology, University of Minnesota, 1980 Folwell Ave, St Paul, MN 55108, USA.
Amelia Ri LindseyDepartment of Entomology, University of Minnesota, 1980 Folwell Ave, St Paul, MN 55108, USA. Electronic address: alindsey@umn.edu.

Funding

Causes and consequences of microbe-mediated asexualityR35GM150991 · NIGMS · UNIVERSITY OF MINNESOTA · PI Amelia Ryan Isis Lindsey · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM150991
6 · The paper itself

Abstract

Insects are rich in reproductive diversity and in maternally inherited symbionts. Maternal inheritance has selected for a suite of microbial mechanisms that enhance host fitness and skew sex ratios in favor of females. Recently, there has been significant progress in characterizing the genetic and cellular mechanisms that these maternally transmitted symbionts use to manipulate insect sex. Significant advances include the identification of specific microbial effector proteins that lead to male-killing, parthenogenesis, and feminization in a range of model and nonmodel insects. Many of these effectors target similar host processes, such as dosage compensation and the sex determination cascade that leads to sex-specific splicing of genes, including transformer and doublesex. The independent origins of these endosymbionts and their induced phenotypes facilitate an enhanced understanding of convergent evolution and offer opportunities to investigate the mechanisms driving insect reproductive diversity.

Indexed as

InsectaSex Determination ProcessesSymbiosisAnimalsFemaleMale

Identifiers

PMID40659090
PMCPMC12315993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.