Evidence map›Paper›PMID 40658893›Full record

ArticleAdvanced healthcare materials2025

Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long-Gap Peripheral Nerve Injury.

Olawale Alimi Alimi, Mitchell Kuss, Wen Xue, Bo Liu, Mena Asha Krishnan, Tianshu Pan, Zhi He, Han-Jun Wang, Yuguo Lei, Kai Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Olawale Alimi AlimiDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0002-0543-4962
Mitchell KussMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Wen XueMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Bo LiuMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mena Asha KrishnanMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Tianshu PanMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Zhi HeMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Han-Jun WangDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yuguo LeiDepartment of Biomedical Engineering, Pennsylvania State University, PA, 16802, USA.
Kai YangDivision of Plastic and Reconstructive Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Bin DuanMary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.ORCID https://orcid.org/0000-0002-5647-3793

Funding

Development of optoelectronically active nerve adhesive for accelerating peripheral nerve repairR21NS131938 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, YU, CUNJIANG · 2023 to 2023
$437k
A Hydrogel Ionic Circuit-Based Electrical Stimulation System for Restoration of Denervated Muscles After Peripheral Nerve InjuriesR21AR078439 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, ZHAO, SIWEI · 2021 to 2022
$378k
NIAMS NIH HHS R21 AR078439NINDS NIH HHS R21 NS131938
6 · The paper itself

Abstract

Severe peripheral nerve injury (PNI) requiring nerve graft remains a clinical challenge due to limitations associated with currently available grafts. While decellularized nerve grafts (DNGs) are commonly used, their efficacy is largely restricted to short-gap repairs due to their acellular and dense structure, which poses a persistent challenge in the treatment of critical long-gap nerve defects. It is hypothesized that making porous DNGs (PDNGs) can create a suitable microenvironment that would facilitate the cell infiltration, recellularization, and further axonal growth to enhance nerve regeneration. In this study, PDNGs are generated and their ability are evaluated to support cell proliferation and penetration in vitro. Their potential to promote nerve regeneration in vivo using a rat model of sciatic nerve transection followed by implantation of a 30 mm-long graft is further evaluated. It is found that PDNGs facilitated greater cellular infiltration within the grafts and enhanced angiogenesis compared to the traditional compact DNGs. In vivo analysis further reveals thicker myelin sheaths in the PDNG group, along with improved axonal alignment. Taken together, PDNGs enhanced nerve regeneration by reorganizing the porous structure into an extracellular matrix that supported cell infiltration, revascularization, and remyelination, all of which contribute to nerve repair.

Indexed as

Nerve RegenerationPeripheral Nerve InjuriesSciatic NerveAnimalsAxonsCell ProliferationDisease Models, AnimalMalePorosityRatsRats, Sprague-DawleyTissue Scaffoldsangiogenesisaxonal alignmentlong gap nerve defectnerve regenerationperipheral nerve injuryporous decellularized nerve graft

Identifiers

PMID40658893
PMCPMC12477580

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.