Evidence map›Paper›PMID 40658772›Full record

ReviewEuropean journal of immunology2025

Innate Lymphoid Cells in Reproductive Health and Disease.

Francesco Colucci, Marco Botta

Abstract readReview
In one paragraph

Review in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Francesco ColucciDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, UK.ORCID 0000-0001-5193-6376
Marco BottaDepartment of Computer Science, University of Turin, Turin, Italy.

Funding

Research grant from King's College, Cambridge to Francesco ColucciWellcome Investigator Award 094073/Z/10/Z
6 · The paper itself

Abstract

Half a kilogram of immune cells reside in tissues. In the uterus, innate lymphoid cells (ILC) contribute to the cyclic destruction and repair of the mucosa. During pregnancy, uterine ILC support the formation of the placenta and the growth of the fetus. They also contribute to immune responses to pathogens. ILC respond quickly to signals of tissue perturbations and, by influencing other immune cells, they organise responses that help maintain tissue health. Their functions have been determined in the respiratory and intestinal tracts, skin, liver and adipose tissue. It is challenging to determine the function of uterine ILC because of the cyclic changes of the endometrium and the difficulties in accessing human tissues during pregnancy. We review the existing literature on the involvement of uterine ILC in physiology and pathology of the non-pregnant endometrium as well as in pregnancy, from implantation of the fertilised egg to the tissue remodelling occurring during the first trimester and that leads to the formation of the placenta which sustains fetal growth, until parturition.

Indexed as

EndometriumImmunity, InnateLymphocytesReproductive HealthUterusAnimalsFemaleHumansPlacentaPregnancyinnate immunityNK cellsplacentareproductive immunologytrophoblast

Identifiers

PMID40658772
PMCPMC12258618

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.