Evidence map›Paper›PMID 40658729›Full record

ArticleCardiovascular research2025

Right stellate ganglion stimulation modulates arrhythmogenesis in acute left lateral ventricular ischaemia.

Joseph Hadaya, Bastiaan J D Boukens, Michiel J Janse, Steven Cha, Al-Hassan Dajani, Ronald Challita, Ruben Coronel, Jeffrey L Ardell, Kalyanam Shivkumar, Veronique M F Meijborg

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Article in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joseph HadayaUCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Bastiaan J D BoukensLaboratory of Experimental Cardiology, Department of Cardiology, LUMC, Leiden, The Netherlands.ORCID 0000-0001-6449-145X
Michiel J JanseDepartment of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, Amsterdam 1100 DD, The Netherlands.
Steven ChaUCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Al-Hassan DajaniUCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Ronald ChallitaUCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Ruben CoronelDepartment of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, Amsterdam 1100 DD, The Netherlands.ORCID 0000-0001-9433-6119
Jeffrey L ArdellUCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Kalyanam ShivkumarUCLA Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Veronique M F MeijborgDepartment of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, P.O. Box 22660, Amsterdam 1100 DD, The Netherlands.ORCID 0000-0002-2358-0170

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
Bioelectric monitoring and control of the heartU01EB025138 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDELL, JEFFREY L, KIPKE, DARYL R · 2017 to 2020
$4.0M
The Intrinsic Cardiac Nervous System and Atrial Pacemakers - Implications for Sinus Node DysfunctionF32HL160163 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HADAYA, JOSEPH ELIAS · 2021 to 2021
$58k
Leducq Foundation 16CVD02NHLBI NIH HHS F32 HL160163NIBIB NIH HHS U01 EB025138NIH HHS OT2 OD023848ODCDC CDC HHS OT2 OD023848
6 · The paper itself

Abstract

aimsAcute myocardial ischaemia causes fatal arrhythmias as result of a flow of 'injury current'. Left stellate ganglion stimulation (LSGS) modulates the injury current and is arrhythmogenic during left anterior ventricular wall ischaemia. The role of right stellate ganglion stimulation (RSGS) in arrhythmogenesis is unclear. We hypothesized that RSGS is proarrhythmic during left lateral ventricular wall ischaemia. METHODS AND

resultsIn 11 anaesthetized female pigs, ventricular repolarization was measured in unipolar epicardial electrograms from the left lateral ventricular wall. Seven subsequent episodes of acute ischaemia (5 min) were produced by occlusion of the circumflex coronary artery (CX), separated by 20 min of reperfusion. The second occlusion served as a control. After 3 min of ischaemia during the third occlusion, LSGS was initiated for 30 s. In the 4th occlusion, RSGS was performed. After decentralization of both left and right stellate ganglia and vagal nerves, LSGS and RSGS were initiated (6th and 7th occlusions). RSGS during ischaemia was more arrhythmogenic than LSGS or control with more spontaneous ventricular premature beats (3-5 min of ischaemia) and two instances of ventricular fibrillation. The LSGS-induced effect on repolarization was absent in myocardium that had been ischaemic for 3 min by CX occlusion.

conclusionsLSGS-induced repolarization shortening is absent in ischaemic myocardium. RSGS was more arrhythmogenic following CX occlusion than LSGS or control. These data demonstrate that the arrhythmogenic influence of RSGS or LSGS is contingent on the location of ischaemic zone supporting the clinical findings that bilateral sympathectomy is superior to left sympathectomy alone.

Indexed as

Arrhythmias, CardiacMyocardial IschemiaStellate GanglionAction PotentialsAcute DiseaseAnimalsDisease Models, AnimalFemaleHeart VentriclesSwineVentricular FibrillationVentricular Premature ComplexesAcute ischaemiaAutonomic modulationInjury currentRepolarizationVentricular arrhythmia

Identifiers

PMID40658729
PMCPMC12352303

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.