Evidence map›Paper›PMID 40658490›Full record

ArticleClinical and experimental rheumatology2026

Predictors of thrombotic events in patients with idiopathic inflammatory myopathies.

Sangmee Sharon Bae, Jennifer Wang, Ani Shahbazian, Daniela Markovic, Yuna Lee, Tiffany De Leon, David Elashoff, Christina Charles-Schoeman

Abstract read
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In one paragraph

Article in Clinical and experimental rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sangmee Sharon BaeDivision of Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA. sbae@mednet.ucla.edu.
Jennifer WangDivision of Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Ani ShahbazianDivision of Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Daniela MarkovicDepartment of Medicine Statistics Core, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Yuna LeeDivision of Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Tiffany De LeonDivision of Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
David ElashoffDepartment of Medicine Statistics Core, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.
Christina Charles-SchoemanDivision of Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.

Funding

Altered High-Density Lipoprotein function in Patients with Idiopathic Inflammatory MyopathiesK23AR081423 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sangmee Bae · 2023 to 2026
$728k
NIAMS NIH HHS K23 AR081423
6 · The paper itself

Abstract

objectivesTo identify predictors of thrombotic events in patients with idiopathic inflammatory myopathies (IIM).

methodsWe conducted a retrospective study of a large, longitudinal IIM cohort followed at a single academic centre. We used Poisson regression models to estimate incidence-rate ratios (IRR) of prospective arterial and venous thrombotic events (ATE and VTE respectively).

resultsThrombotic events occurred in 37 out of 312 patients (12%) over a median [interquartile range (IQR)] follow up time of 6[2-11] years after IIM diagnosis. Among patients with thrombotic events, 65% had VTE, which predominantly occurred within the first 3 years of IIM diagnosis, while 41% had ATE, which predominantly occurred after 10 years from IIM diagnosis. In predictive models, disease duration less than 1 year (IRR 6.49, 95%CI 1.89-22.35) was the strongest risk factor for VTE. Prior ATE was the strongest risk factor for prospective ATE (IRR 18.78, 95%CI 10.98-32.12). Traditional cardiovascular (CV) risk factors and higher levels of myositis activity and damage were other predictors of prospective ATE. The lactonase activity of PON1 was independent of the PON1 Q192R polymorphism and enhanced prediction of ATE in patients with high CV risk. IVIG was not associated with increased thrombotic risk in a high-risk population.

conclusionsWe report the incidence and risk factors for thrombotic events in a single-centre longitudinal IIM cohort, showing early occurrence of VTE and late onset of ATE. PON1 activity was predictive of ATE in a high-risk subgroup of IIM patients.

Indexed as

MyositisThrombosisAdultAgedFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentRisk FactorsTime Factors

Identifiers

PMID40658490
PMCPMC13211941

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.