ArticleIntensive care medicine2025
Source control in bloodstream infections in patients with sepsis, septic shock, or requiring ICU admission: a scoping review with recommendations for standardizing research.
Article in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).Intensive care medicine · 2026Article
- Care Pathway and Outcomes in Pediatric Septic Shock: A Narrative Review from Emergency Department Recognition to PICU Management.Children (Basel, Switzerland) · 2026Review
- Update on sepsis and septic shock: from bundles to precision medicine.Intensive care medicine · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBloodstream infections (BSI) account for 15% of intensive care unit (ICU) infections, often causing sepsis with mortality rates up to 50%. Source control (SC), encompassing interventions to reduce bacterial or fungal load and prevent infection spread, is a critical yet under-investigated component of management.
objectivesThis scoping review examines SC definitions, interventions, timing, adequacy, and outcomes in BSI literature in patients with sepsis, septic shock, or ICU admission, and offers a proposal for standardized reporting.
methodsWe searched Medline, EMBASE, and Cochrane Library for studies on adult BSI addressing SC in populations with ≥ 50% ICU admission, ≥ 75% sepsis, or ≥ 25% septic shock, extracted and reported data following established guidance.
resultsFrom 2193 abstracts, 77 studies were included. SC was a primary objective in 21%, with others reporting it alongside other objectives. Candidemia (47%) and catheter removal (60%) studies were predominant, with 34% evaluating catheter removal regardless of BSI source. SC definitions varied from no definition (8%), minimal (7%), concise (17%), comprehensive (9%) definitions and catheter removal (60%). Forty-seven % reported proportions receiving SC for the entire cohort rather than those requiring SC. Timing was reported by 68%, with inconsistent definitions. SC adequacy was assessed by 3%. SC improved outcomes in 65%, with no reported harm.
conclusionSC research in severe BSI is limited by inconsistent definitions, poor SC efficacy assessments, and overrepresentation of catheter-source BSI and candidemia. Standardized reporting is essential to enhance evidence quality and optimize BSI management in critically ill patients.
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