SynthesisEndocrine2025
Safety of surgery for managing hyperthyroidism in patients with or without preoperative euthyroidism: A systematic review and meta-analysis.
Synthesis in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Plasma exchange aids thyroidectomy in refractory amiodarone-induced thyrotoxicosis, despite variable biochemical responses.European thyroid journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines recommend achieving normal thyroid function (euthyroidism) before thyroid surgery to treat hyperthyroidism due to concerns about uncontrolled thyroid hormone release during surgery. However, achieving euthyroidism before surgery may not always be possible. We aim to evaluate postoperative outcomes of hyperthyroid patients who were euthyroid versus those who were not before thyroid surgery.
methodsWe searched Medline, Embase, Scopus, and Cochrane from inception to July 2023 to identify comparative studies on hyperthyroid patients who were euthyroid or hyperthyroid (elevated thyroxine levels) before surgery. We evaluated post-surgical complication rates in each group. A random-effects model was used to consolidate dichotomous variables with odds ratios (OR) and continuous variables with mean differences (MD), both with 95% confidence intervals (95% CI). The risk of bias was assessed using the Newcastle-Ottawa Scale.
resultsWe included eight retrospective cohort studies involving 1336 patients, of whom 33.6% (n = 449) were biochemically hyperthyroid at the time of thyroidectomy. Most of these patients were female (67.2%, n = 899), with an average age (SD) of 38.73 ± 2.80 years, and had Graves' Disease (96%). The mean (SD) preoperative TSH was 0.28 ± 0.10 mIU/L, FT4 was 3.33 ± 0.64 ng/dL, and FT3 was 67.65 ± 22.41 pg/mL. No significant differences were observed in postoperative complications between preoperatively euthyroid and hyperthyroid patients. This includes temporary hypocalcemia (OR: 0.50, 95% CI: 0.20-1.29, I
conclusionsLow-to-moderate quality evidence suggests preoperatively euthyroid patients undergoing total thyroidectomy have lower risks of hypocalcemia, hoarseness, and hematoma than hyperthyroid patients, though differences are not statistically significant. These findings can guide recommendations for hyperthyroidism management and help clinicians weigh surgical risks and benefits for hyperthyroid patients.
Indexed as
Identifiers
40658187What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.