Evidence map›Paper›PMID 40658184›Full record

ArticleDiscover oncology2025

Nodal metastasis in surgically treated sinonasal squamous cell carcinoma.

Jacob E Hoerter, Si Hao Tang, Jacob G Eide, Mandy K Salmon, Ryan M Carey, Aman Prasad, Jason A Brant, James N Palmer, Nithin D Adappa, Rijul S Kshirsagar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacob E HoerterDepartment of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.
Si Hao TangDrexel University College of Medicine, Philadelphia, PA, USA.
Jacob G EideDepartment of Otolaryngology, Henry Ford Health System, Detroit, MI, USA.
Mandy K SalmonDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Ryan M CareyDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Aman PrasadDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Jason A BrantDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
James N PalmerDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Nithin D AdappaDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Rijul S KshirsagarDepartment of Head and Neck Surgery, Kaiser Permanente Redwood City Medical Center, 905 Maple St., Redwood City, CA, 94063, USA. rijul.kshirsagar@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTumor factors such as subsite and stage impact the risk of lymph node metastasis (LNM) and overall risk in sinonasal squamous cell carcinoma (SNSCC). We sought to identify the rates of patients presenting with or without clinical LNM for different tumor subsites and stages of surgically-treated SNSCC, determine the concordance between clinical and pathologic LNM after neck dissection (ND), and identify predictors of occult LNM.

methodsThe National Cancer Database was queried for patients with surgically-treated SNSCC from 2004 to 2016. For patients presenting with clinical LNM, rates of pathologic LNM and node negativity were determined following ND. For patients without clinical LNM, rates of elective neck dissection (END) and occult LNM were calculated. Predictors of occult LNM were identified using multivariate logistic regression.

results1,964 patients were included; primary tumor subsites included nasal cavity (55.7%), maxillary (37.8%), and ethmoid sinuses (6.5%). Clinical LNM rates at presentation were 14.3% overall and 25.3% for the maxillary sinus; clinical LNM rates increased with tumor stage. 30.8% of patients with clinical LNM were pN0 following ND. Only 15.3% of patients underwent END; advanced age (> 75 years) (OR 8.17 [1.59-64.7]), presence of lymphovascular invasion (LVI) (OR 8.68 [2.63-30.2]) and unknown LVI status (OR 4.48 [1.17-16.2]) were associated with significantly higher risk of occult LNM.

conclusionsRates of occult LNM differed by subsite and tumor stage for surgically managed SNSCC. Rates of occult LNM were increased with older age and presence of LVI. Additional studies are necessary to determine the benefit of END in SNSCC.

Indexed as

Head and neckLymph node dissectionNodal metastasisSquamous cell carcinoma

Identifiers

PMID40658184
PMCPMC12260143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.