ArticleJournal of materials science. Materials in medicine2025
Elastic modulus of hyaluronic acid hydrogels by compression testing.
Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Tailorable Hydrogel Fibers from High-Yield Recombinant Hagfish Intermediate Filament Proteins: A New Frontier in Biomimetic Materials.ACS omega · 2026Article
- Smart responsive hydrogels combined with AI design for tumor therapy.Acta pharmaceutica Sinica. B · 2026Review
- Light-Driven Self-Pulsating Hydrogel with a Sliding-Delay Mechanism for Micro-Actuation and Microfluidic Applications.Micromachines · 2026Article
- Interpretable Machine Learning Insights into Adhesion and Modulus of Biomedical HA-Dopamine Hydrogels.Gels (Basel, Switzerland) · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
Hyaluronic acid was crosslinked using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide to form hydrogels with low elastic modulus. These hydrogels were swollen in water and the elastic modulus was obtained with a contact mechanics approach in ambient conditions using a low-load mechanical tester under compression. The modulus was measured during both the approach and retraction of the cylindrical probe into the gel and was found to be of the order of 30 kPa. The modulus was also measured from a stress-strain curve (47 kPa), in reasonable agreement with the contact mechanics approach. However, nanoindentation and rheology measurements reveal much smaller moduli, indicating that the technique used interrogates different length scales within the gel. This has profound implications for the applications of hydrogels used, for example, in tissue engineering. The values reported here are likely to be appropriate for applications where contact with the spinal cord is necessary. It is argued that a contact mechanics approach is appropriate for the characterization of hydrogels for applications designed for contact with tissue.
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