ArticleInternational journal of cancer2025
Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci.
Abstract read
In one paragraph
Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
63 authors.
Guochong JiaDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jie PingDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-9907-5819
Ran TaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lili LiuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Shuai XuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Heather M MunroInternational Epidemiology Field Station, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Stefan AmbsLaboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Mollie E BarnardSlone Epidemiology Center, Boston University, Boston, Massachusetts, USA.
Yu ChenDivision of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-1519-4894
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Yu-Tang GaoState Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Montserrat Garcia-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Jian GuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-3499-0973
Jennifer J HuDepartment of Public Health Sciences, University of Miami School of Medicine, Miami, Florida, USA.
Motoki IwasakiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.ORCID 0000-0003-3319-4131
Esther M JohnDepartments of Epidemiology & Population Health and of Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-3259-8003
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Hwasun, South Korea.
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID 0000-0003-1761-6314
Katherine NathansonDivision of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Barbara NemesureDepartment of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
Tuya PalDivision of Genetic Medicine, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.ORCID 0000-0001-5002-9707
Boyoung ParkDepartment of Preventive Medicine, Hanyang University College of Medicine, Seoul, South Korea.ORCID 0000-0003-1902-3184
Michael F PressDepartment of Pathology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Maureen SandersonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee, USA.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
Song YaoDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Ying ZhengShanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Prisca O AdejumoDepartment of Nursing, College of Medicine, University of Ibadan, Nigeria.
Thomas AhearnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Abenaa M BrewsterDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Anselm J M HennisDepartment of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Hidemi ItoDivision of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan.ORCID 0000-0002-8023-4581
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Eun-Sook LeeNational Cancer Center Graduate School of Cancer Science and Policy, Goyang, South Korea.
Siew-Kee LowRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Timothy MakumbiDepartment of Surgery, Mulago Hospital, Kampala, Uganda.
Paul NdomYaounde General Hospital, Yaounde, Cameroon.
Dong-Young NohCollege of Medicine, Cancer Research Institute, Seoul National University, Seoul, South Korea.
Katie M O'BrienEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.ORCID 0000-0002-1931-1349
Andrew F OlshanDepartment of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Mojisola M OluwasanuDepartment of Health Promotion and Education, College of Medicine, University of Ibadan, Nigeria.
Min-Ho ParkDepartment of Surgery, Chonnam National University Medical School, South Korea.
Sonya ReidDivision of Hematology and Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Taiki YamajiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan.ORCID 0000-0002-4799-8782
Gary ZirpoliSlone Epidemiology Center, Boston University, Boston, Massachusetts, USA.
Ebonee N ButlerDepartment of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Maosheng HuangDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Atara NtekimDepartment of Radiation Oncology, College of Medicine, University of Ibadan, Nigeria.
Clarice R WeinbergBiostatistics and Computational Biology Branch, National Institutes of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Bingshan LiDepartment of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee, USA.
Dezheng HuoDepartment of Public Health Sciences, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-4041-1678
Daehee KangDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.ORCID 0000-0003-4031-5878
Christine AmbrosoneDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Melissa A TroesterDepartment of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, California, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-0711-8314
Julie R PalmerSlone Epidemiology Center, Boston University, Boston, Massachusetts, USA.
Xingyi GuoDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-1226-070X
Funding
Breast Cancer genetic study in African-ancestry populationsR01CA202981 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wei Zheng · 2016 to 2026
$14.1MIntegrating genomic and transcriptomic data to identify breast cancer susceptibility genesR01CA235553 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LONG, JIRONG, ZHENG, WEI · 2019 to 2024
$3.3MConsortium Study to Identify Breast Cancer Susceptibility LociR01CA148667 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LONG, JIRONG, ZHENG, WEI · 2011 to 2015
$3.3MGenetic Factors for Breast Cancer- A genome Wide StudyR01CA124558 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 2008 to 2012
$3.1MIntramural NIH HHS Z99 ES999999NCI NIH HHS R01 CA124558NCI NIH HHS R01 CA148667NCI NIH HHS R01 CA202981NCI NIH HHS R01 CA235553U.S. National Institutes of Health R01CA124558U.S. National Institutes of Health R01CA148667U.S. National Institutes of Health R01CA202981U.S. National Institutes of Health R01CA235553
Abstract
Genome-wide association studies (GWAS) have identified more than 200 risk loci for breast cancer. However, target genes and their encoded proteins in these loci remain largely unknown. In this study, we utilized genetic prediction models for 1349 circulating proteins derived from individuals of African (n = 1871) and European (n = 7213) ancestry to investigate genetically predicted protein levels in association with breast cancer risk among females of African (n = 40,138), Asian (n = 137,677), and European (n = 247,173) ancestry. We identified 51 blood protein biomarkers associated with breast cancer risk, overall or by subtypes, at a false discovery rate (FDR) < 0.05, including 27 proteins encoded by genes located at least 1 Mb away from any of the known risk loci identified in GWAS. Of them, 32 proteins showed significant associations with breast cancer risk at the Bonferroni-corrected significance level (p < 2.45 × 10
Indexed as
Biomarkers, TumorBreast NeoplasmsAsian PeopleFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansMiddle AgedPolymorphism, Single NucleotideProteomicsRisk FactorsWhite PeopleBiomarkers, Tumorbiomarkerbreast cancermulti‐ancestryplasma protein
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.