Evidence map›Paper›PMID 40657929›Full record

ArticleJournal of bacteriology2025

The PDZ domain of EpsC is required for extracellular secretion of VesB by the Type II secretion system in

Austin Shannon, Tanya Johnson, Cameron S Roberts, Catherine T Chaton, Konstantin V Korotkov, Maria Sandkvist

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. A 3'UTR-derived small RNA modulates the life cycle of the cholera toxin-encoding filamentous phage, CTXϕ.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Frontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Austin ShannonDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Tanya JohnsonDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Cameron S RobertsDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Catherine T ChatonDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.
Konstantin V KorotkovDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-2182-6843
Maria SandkvistDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-6605-4720

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Molecular Mechanisms of Protein Sorting by the Type II Secretion SystemR01AI137085 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDKVIST, MARIA B · 2018 to 2022
$2.0M
Post-translational modification of GlyGly-Cterm ProteinsF32AI178852 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERTS, CAMERON · 2023 to 2025
$238k
NIAID NIH HHS F32 AI178852NIAID NIH HHS R01 AI137085NIAID NIH HHS T32 AI007528NIH HHS F32AI178852NIH HHS R01AI137085NIH HHS T32AI007528
6 · The paper itself

Abstract

The Type II Secretion System (T2SS) of the Gram-negative pathogen IMPORTANCE: The T2SS is common in Gram-negative pathogens, facilitating the secretion of various toxins and enzymes; however, the mechanisms of substrate selection and secretion remain poorly understood. Here, we demonstrate that the C-terminal PDZ domain of the T2SS "clamp" protein EpsC is only required for secretion of VesB in

Indexed as

Bacterial ProteinsPDZ DomainsSerine EndopeptidasesType II Secretion SystemsVibrio choleraeGene Expression Regulation, BacterialBacterial ProteinsSerine EndopeptidasesType II Secretion SystemsAviTag biotinylationGspCIg domainPDZ domainperiplasmic retentionsecretion signalserine proteasesubstrate selectionT2SStype II secretion systemVibrio cholerae

Identifiers

PMID40657929
PMCPMC12369372

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.