ArticleMicrobiology spectrum2025
Therapeutic and prophylactic effects of Qipian on COPD in mice: the role of lung and gut microbiota.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global research status and development trends of chronic obstructive pulmonary disease and gut microbiota: a comprehensive analysis based on bibliometrics and knowledge visualization.Frontiers in microbiology · 2026Pooled it
- Cigarette smoke extract exposure induces gut microbial dysbiosis and impairs short-chain fatty acid metabolism in juvenile rats.Pediatric research · 2026Article
- Qingxuan Zhike Granules Modulate Gut Dysbiosis and Enhance Intestinal Repair in MurineJournal of microbiology and biotechnology · 2026Article
- The gut-lung axis in COPD: immunomodulatory roles of gut microbiota and novel therapeutic strategies.Frontiers in immunology · 2026Review
- The gut-lung axis: a new perspective on the impact of atmospheric particulate matter exposure on chronic obstructive pulmonary disease.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate the therapeutic and prophylactic effects of the mixed extract of Staphylococcus and Neisseria tablets (Qipian) on chronic obstructive pulmonary disease (COPD) in mice and its relationship with lung and gut microbiota. C57BL/6 mice were divided into two models (prophylactic versus therapeutic administration). In the model of prophylactic administration, the mice were exposed to cigarette smoke (CS) for 16 weeks and divided into CS+Qipian group, CS+OM-85 group, and CS control group. Compared to the CS control group, mice in both CS+Qipian and CS+OM-85 groups had improved lung function, reduced pulmonary bullae and inflammatory cell infiltration, reduced collagen deposition around the bronchi, and decreased levels of inflammatory cytokines in the lung tissue. Qipian and OM-85 significantly increased the diversity of gut and lung microbiota and the abundance of Bacteroidetes,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.