ArticleJournal of the International Neuropsychological Society : JINS2025
History of chronic pain and opioid use is associated with cognitive decline and mild cognitive impairment.
Article in Journal of the International Neuropsychological Society : JINS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Chronic pain as a risk factor for Alzheimer's disease pathology: a longitudinal ADNI study.Alzheimer's research & therapy · 2026Article
- Subjective memory concerns and cognitive aging in Puerto Rican older adults: the moderating role of chronic pain.Innovation in aging · 2026Article
- Episodic Memory, Chiari I Malformation, Personality and Coping: The Role of Chronic Pain.Behavioral sciences (Basel, Switzerland) · 2025Review
- Chronic pain and subjective memory problems are dynamic risk factors for functional decline: An ACTIVE longitudinal study.Experimental gerontology · 2025Article
- The Silent Cognitive Burden of Chronic Pain: Protocol for an AI-Enhanced Living Dose-Response Bayesian Meta-Analysis.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundThe impact of chronic pain and opioid use on cognitive decline and mild cognitive impairment (MCI) is unclear. We investigated these associations in early older adulthood, considering different definitions of chronic pain.
methodsMen in the Vietnam Era Twin Study of Aging (VETSA;
resultsModerate-to-severe, but not mild, chronic pain intensity ( DISCUSSION: Moderate-to-severe chronic pain intensity and interference related to executive function decline and greater risk of non-amnestic MCI; while opioid use related to verbal fluency decline and greater risk of amnestic MCI. Lowering chronic pain severity while reducing opioid exposure may help clinicians mitigate later cognitive decline and dementia risk.
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Registered trials
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