Evidence map›Paper›PMID 40657853›Full record

ArticleJournal of leukocyte biology2025

Human neutrophils are a cellular source of apolipoprotein A-I.

Xianglan Yao, Joni Mills, Pradeep K Dagur, Wan-Chi Lin, Maria Lopez-Ocasio, Meixia Gao, Zu-Xi Yu, Kazuyo Takeda, Karen J Keeran, Ick Ho Kim and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xianglan YaoLaboratory of Asthma and Lung Inflammation, Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0003-0668-0353
Joni MillsLaboratory of Asthma and Lung Inflammation, Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Pradeep K DagurFlow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Wan-Chi LinFlow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Maria Lopez-OcasioFlow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Meixia GaoLaboratory of Asthma and Lung Inflammation, Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Zu-Xi YuPathology Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Kazuyo TakedaPathology Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Karen J KeeranAnimal Surgery and Resources Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0003-4224-8568
Ick Ho KimLaboratory of Asthma and Lung Inflammation, Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Amisha V BarochiaLaboratory of Asthma and Lung Inflammation, Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Stewart J LevineLaboratory of Asthma and Lung Inflammation, Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0001-9313-9746

Funding

Fiberoptic Bronchoscopy in Patients with AsthmaZIAHL006197 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVINE, STEWART · 2015 to 2024
$14.8M
Intramural NIH HHS ZIA HL006197the Division of Intramural Research at the National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland
6 · The paper itself

Abstract

Apolipoprotein A-I (APOA1), the major protein of high-density lipoproteins, has anti-inflammatory functions. APOA1 is primarily produced in the liver; however, it is not known whether neutrophils are a cellular source. Here, we assessed whether human neutrophils express APOA1. Peripheral blood and bronchoalveolar lavage fluid (BALF) were obtained from healthy volunteers (HVs) and asthmatics. Peripheral blood neutrophils from HVs expressed APOA1 at both the mRNA and protein levels, while confocal microscopy demonstrated that APOA1 was localized to a unique population of intracytoplasmic granules. In HVs and asthmatics, APOA1 was preferentially expressed by neutrophils with high side-scatter (SSChigh) in blood and BALF. Furthermore, APOA1+ SSChigh neutrophils were characterized as a population with high levels of caspase-3/caspase-7 activation and CCR5 expression. Since APOA1 has anti-inflammatory functions, this suggests that APOA1 expression by neutrophils may represent a mechanism to attenuate excessive inflammatory responses in health and disease.

Indexed as

Apolipoprotein A-IAsthmaNeutrophilsAdultBronchoalveolar Lavage FluidFemaleHumansMaleMiddle AgedRNA, MessengerAPOA1 protein, humanApolipoprotein A-IRNA, Messengerapolipoprotein a-Ibloodbronchoalveolar lavage fluidhumanneutrophils

Identifiers

PMID40657853
PMCPMC12407566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.