SynthesisCancer medicine2025
Fertility-Related Concerns in Survivors of Childhood Cancer: A Systematic Review.
Synthesis in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fertility-Related Concerns in Survivors of Childhood Cancer: A Systematic Review.Cancer medicine · 2025Pooled it
- Infertility costs and associated factors in childhood cancer survivors: the role of radiotherapy.Journal of cancer survivorship : research and practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveChildhood cancer survivors are at increased risk for treatment-related fertility impairment and subsequent fertility-related concerns. However, there is currently no consensus on how to define, assess, and address these concerns in clinical practice. Therefore, we aimed to answer the following questions: (1) How are fertility-related concerns assessed and defined? (2) What types of fertility-related concerns are reported by survivors, and how common are they? (3) What clinical implications are proposed in the literature?
methodsWe systematically searched the databases PubMed, PsycINFO, MEDLINE, CINAHL, and Embase for peer-reviewed publications on fertility-related concerns in survivors of childhood cancer published between January 1990 and November 2023. The search yielded 2077 potentially relevant articles, of which eleven met inclusion criteria and were included. Furthermore, we screened the reference lists of included studies, leading to a total of N = 25 studies included in the narrative synthesis.
resultsWe identified considerable variation in the assessment, description, and definition of fertility-related concerns. Survivors described fertility-related concerns in terms of their personal and reproductive health, the health of their (future) children, and dating and romantic relationships. Concerns were reported by 9.5% to 65% of survivors in quantitative studies. Suggestions for clinical implications included that different healthcare providers could use individual or group strategies to address fertility-related concerns. They should focus on patient reports rather than parent-proxy reports and assess individual fertility-related preferences and attitudes without making assumptions.
conclusionsFertility-related concerns are common among childhood cancer survivors and need to be addressed by care providers and researchers in the field. To do so effectively, we need more consistency in assessing, labeling, and defining these concerns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.