Evidence map›Paper›PMID 40657793›Full record

ArticleFuture science OA2025

Identification of the important role of CA9 in immune infiltration and prognosis in cervical cancer.

Zhi Zhao, Xin Chen, Yajuan Feng, Yiming Lei, Xihong Deng, Rubing Lin, Jiang Ling, Zhaojuan Hou, Yuanyuan Yang, Zhenyu Zhu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhi ZhaoDepartment of Pathology, Zhengzhou Yihe Hospital, Henan University, Zhengzhou, Henan, China.
Xin ChenDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yajuan FengFirst Ward of the Respiratory and Critical Care Medicine Department of Henan Provincial People's Hospital, ZhenZhou, Henan, China.
Yiming LeiGeorgia Institute of Technology, GA, USA.
Xihong DengClinical medical school, Jilin Medical University, Jilin City, China.
Rubing LinDepartment of Orthopedics, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Jiang LingDepartment of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
Zhaojuan HouClinical Research Center for Women's, Reproductive Health in Hunan Province, Changsha, Hunan, China.
Yuanyuan YangClinical Research Center for Women's, Reproductive Health in Hunan Province, Changsha, Hunan, China.
Zhenyu ZhuDepartment of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aimed to investigate the association between CA9 expression and the immune infiltration and prognosis of CC. MATERIALS &

methodsThe GSE9750 dataset in the GEO database, the UALCAN database, and the cBioPortal of cervical squamous cell carcinoma study were used for bioinformatic analysis, followed by validation via immunohistochemistry in clinical samples.

resultsCompared to normal controls, CC samples showed 1175 significantly downregulated and 698 significantly upregulated genes, respectively. Specifically, CA9 was identified among the up-regulated genes, with verification by analysis of TCGA data. The overexpression of CA9 in CC was further confirmed in clinical samples. The protein-protein interaction network results revealed that CA9 was closely associated with 12 genes, which were widely involved in cancer-related processes such as cell proliferation, migration, and metabolism. CA9 was associated with tumor histological subtypes, hypoxia scores, low immune infiltration, poor survival rate, and specific microorganisms.

conclusionOur study indicated that CA9 was upregulated in CC and closely related to tumor immune microenvironment, thereby becoming an important prognostic factor for CC. This study highlights CA9 as a potential diagnostic and therapeutic target for the disease.

Indexed as

biomarkerCA9Cervical cancerimmune infiltrationprognostic marker

Identifiers

PMID40657793
PMCPMC12269681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.