Evidence map›Paper›PMID 40657791›Full record

Observational studyCancer medicine2025

Trajectories of Symptom Clusters and Their Predictive Factors in Patients With Colorectal Cancer 3 Months After Surgery: A Longitudinal Study.

Yue Li, Wenwen Gan, Qin Mao, Hongying Wu, Ting Cao, Haiyan Wu, Xiaorong Mao

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yue LiDepartment of Nursing, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Wenwen GanDepartment of Nursing, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Qin MaoDepartment of Nursing, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Hongying WuDepartment of Nursing, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Ting CaoDepartment of Nursing, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Haiyan WuDepartment of Nursing, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Xiaorong MaoDepartment of Nursing, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID https://orcid.org/0000-0003-4407-2471

Funding

Health Science Research Project of Sichuan Province 2024-231
6 · The paper itself

Abstract

aimsTo examine the changing trajectories of symptom clusters within 3 months following surgery in patients with colorectal cancer (CRC) and identify their predictive factors.

designA prospective longitudinal observational study.

methodsConvenience sampling was used to recruit inpatients with CRC who were scheduled for surgical treatment at the Sichuan Provincial People's Hospital between October 2022 and September 2023. The Chinese version of the MD Anderson Symptom Inventory Gastrointestinal Cancer Module was utilized. The prevalence and severity of patients' symptoms were assessed at 7 days (T1), 6 weeks (T2), and 3 months (T3). Before the operation, a total of 240 patients with CRC were recruited. There were 203, 164, and 139 patients participating in T1, T2, and T3, respectively. Exploratory factor analysis identified symptom clusters. Latent class growth modeling determined the developmental trajectories of symptom clusters, and binomial logistic regression analyzed predictors of trajectory classification.

resultsTwo clinical subgroups were identified: a "high symptom-decreases and then increases" (17.2%) and a "low symptoms-continuous decline" (82.8%). The latter exhibited significantly lower and progressively declining symptom severity compared to the former. Predictive factors for the "high symptom-decreases and then increases" subgroup included multimorbidity (≥ 2 chronic conditions), chronic lung disease, preoperative frailty, severe anxiety/depression, open surgery, and postoperative chemotherapy.

conclusionsTargeted management of the mood-sleep disorder cluster (T1) and the activity intolerance cluster (T2/T3) may significantly improve patients' quality of life. The "high symptom-decreases then increases" subgroup warrants prioritized clinical attention, as early intervention for its predictive factors (e.g., frailty, anxiety, and depression) could enhance postoperative outcomes. Integrating these factors into routine preoperative assessments is recommended.

Indexed as

Colorectal NeoplasmsAdultAgedDepressionFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesQuality of LifeSeverity of Illness Indexcolorectal neoplasmsconvalescencelongitudinal studiesperioperative periodpredictive factorssubgroup analysissymptom clusterstrajectories

Identifiers

PMID40657791
PMCPMC12257499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.