ArticleAmerican journal of physiology. Heart and circulatory physiology2025
The effects of limb suction during arterial occlusion on arterial baroreflex in humans.
Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Peripheral venous distension evokes a reflex sympathetic activation [venous distension reflex (VDR)]. Previous study showed that venous distension in a forearm with a volume infusion raised sympathetic baroreflex sensitivity (SBRS). However, the effects of venous distension on baroreflex sensitivity (BRS) in the lower limb have not been examined. We hypothesized that the venous distension in an upper or lower limb by the negative pressure would alter BRS. In 20 healthy subjects, one arm or one leg of the subjects was placed into an airtight pressure tank, although a cuff was placed proximally on the limb. A negative pressure of 100 mmHg was applied for 2 min, although the limb was arterially occluded [occlusion and suction (O&S)]. Arm- or leg-occlusions without negative pressure were performed for 2 min as control trials. Beat-by-beat blood pressure (BP), heart rate, and muscle sympathetic nerve activity (MSNA) were recorded. SBRS and the cardiovagal BRS (CBRS) were calculated. BP and MSNA were significantly increased by arm-O&S and leg-O&S (all,
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