Evidence map›Paper›PMID 40657739›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer-Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders.

Yongqiang Xiao, Xinyue Wang, Ming Liu, Xiao Fu, Nanfeng Zhang, Wenqing Yang, Junyi Ge, Yangyang Li, Duan Ma, Jing Ma and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Mucus Plugs and Eosinophilic Inflammation: Expanding the Paradigm to COPD.The journal of allergy and clinical immunology. In practice · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yongqiang XiaoENT Institute, Department of Facial Plastic and Reconstructive Surgery, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Xinyue WangENT Institute, Department of Facial Plastic and Reconstructive Surgery, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Ming LiuDepartment of Otolaryngology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, China.
Xiao FuDepartment of Otology and Skull Base Surgery, EYE and ENT Hospital of Fudan University, Shanghai, 200031, China.
Nanfeng ZhangDepartment of ENT, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230031, China.
Wenqing YangDepartment of ENT, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230031, China.
Junyi GeKey Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yangyang LiDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200021, China.
Duan MaKey Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Jing MaENT Institute, Department of Facial Plastic and Reconstructive Surgery, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Weiping WenDepartment of Otolaryngology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, China.
Dongdong RenDepartment of Otology and Skull Base Surgery, EYE and ENT Hospital of Fudan University, Shanghai, 200031, China.
Tianyu ZhangENT Institute, Department of Facial Plastic and Reconstructive Surgery, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Zhaoxu TuDepartment of Otolaryngology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, China.ORCID https://orcid.org/0000-0001-7020-5325

Funding

China Postdoctoral Science Foundation 2022M720787National Natural Science Foundation of China 82071055National Natural Science Foundation of China 82200910National Natural Science Foundation of China 82202455National Natural Science Foundation of China 82271188Young Elite Scientists Sponsorship Program by CAST 2022QNRC001
6 · The paper itself

Abstract

Excessive generation of neutrophil extracellular traps (NETs) and eosinophil extracellular traps (EETs) can drive various inflammatory disorders by stimulating intracellular nucleic acid receptors. Although extracellular traps (ETs) are promising therapeutic targets for recalcitrant chronic inflammation, for example, otitis media with effusion (OME), practical and specific targeting of NETs/EETs in pathological tissues remains challenging. In this study, an ultrathin, 2D sheet-like nanoscavenger C-TA

Indexed as

Aptamers, NucleotideEosinophilsExtracellular TrapsInflammationNanostructuresNeutrophilsAnimalsDisease Models, AnimalMaleRatsAptamers, Nucleotideaptamerscopper indium thiophosphatedysregulated inflammationneutrophil/eosinophil extracellular trapstannic acid

Identifiers

PMID40657739
PMCPMC12520462

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.