ArticleJournal of applied clinical medical physics2025
Analysis of treatment planning time and optimization parameters for inverse planning for intracavitary and interstitial brachytherapy in uterine cervical cancer.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Analysis of treatment planning time and optimization parameters for inverse planning for intracavitary and interstitial brachytherapy in uterine cervical cancer.Journal of applied clinical medical physics · 2025Article
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8 authors.
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Abstract
purposeThis study aimed to investigate the effect of inverse planning parameters on dose-volume indices in brachytherapy for uterine cervical cancer.
methodsFourteen consecutive patients with cervical cancer who received intracavitary and interstitial brachytherapy (IC/ISBT) were selected. Tandem, ovoid, and interstitial needles were used in all cases. The evaluation plans were recalculated from the first fraction of clinical brachytherapy plans. The correlation between the 11 dose optimization parameters of inverse planning and the 13 dose-volume indices was evaluated. The parameters were adjusted in five levels, and dose optimization was performed in hybrid inverse planning optimization (HIPO). Spearman's rank correlation and multiple regression analyses were conducted to assess the association between the parameters and the indices. The indices included clinical target volume (CTV) dose, organ-at-risk (OAR) dose, homogeneity, and conformity. Additionally, the correlation between optimization parameters and calculation time was investigated, along with a technique for efficiently generating treatment plans.
results"CTV Max Weight" and "OAR Max Weight" were the key parameters significantly affecting the indices. Increasing "CTV Max Weight" improved homogeneity but reduced the target coverage. The effect of "OAR Max Weight" on the dose reduction of CTV
conclusion"CTV Max Weight" and "OAR Max Weight" were the most influential parameters in HIPO, significantly affecting dose-volume indices in IC/ISBT for uterine cervical cancer. Additionally, parameters that regulate the hyper-dose sleeve and needle-delivered dose were identified. The quality of treatment planning can be maintained and planning time reduced by appropriately optimizing these parameters.
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