Evidence map›Paper›PMID 40657674›Full record

ArticleJournal of applied clinical medical physics2025

Pelvic dose accumulation accuracy in a CBCT based online adaptive radiotherapy system.

Mikel Byrne, Xenia Ray, Kelly Kisling, Ben Archibald-Heeren, Robert Finnegan, Suhuai Luo, Trent Aland, Peter Greer

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. First dosimetric evaluation of deformable dose accumulation in human individuals.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mikel ByrneIcon Group, South Brisbane, QLD, Australia.
Xenia RayDepartment of Radiation Medicine and Applied Sciences, UC San Diego Health, San Diego, California, USA.
Kelly KislingDepartment of Radiation Medicine and Applied Sciences, UC San Diego Health, San Diego, California, USA.
Ben Archibald-HeerenIcon Group, South Brisbane, QLD, Australia.
Robert FinneganNorthern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, NSW, Australia.
Suhuai LuoSchool of Information and Physical Sciences, University of Newcastle, Newcastle, NSW, Australia.
Trent AlandIcon Group, South Brisbane, QLD, Australia.
Peter GreerSchool of Information and Physical Sciences, University of Newcastle, Newcastle, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAccurate dose accumulation is essential for understanding the delivered dose in online adaptive radiotherapy (OART). The aim of this study is to quantify the dose accumulation accuracy and clinical significance of dose accumulation errors in pelvis treatments using the Ethos v1.1 and v2.0 systems.

methodThree pelvic CTs had anatomically realistic deformation vector fields (DVF) applied to create new modified images. These modified images were then used as treatment images in simulated OART treatment sessions, and the dose was accumulated by the Ethos system (D(fx)

resultsLarge discrepancies in deformable registration magnitude were noted between the applied DVF and the Ethos DVF from both Ethos versions. All Ethos v1.1 results had 90% of points passing a 3%/2 mm gamma analysis, whilst Ethos v2.0 results did not reach this benchmark in all of the simulated scenarios. Results were particularly poor for the v2.0 prostate case. Inaccuracies in the dose accumulation process caused 6% of goals to change sufficiently such that the goal was reported as met or exceeded when it was not.

conclusionThe Ethos v1.1 dose accumulation system has been found to perform acceptably for the pelvic CTs tested in this study. For the Ethos v2.0 system substantial discrepancies in the dose accumulation were noted.

Indexed as

Cone-Beam Computed TomographyImage Processing, Computer-AssistedPelvisPhantoms, ImagingProstatic NeoplasmsRadiotherapy, Image-GuidedRadiotherapy Planning, Computer-AssistedAlgorithmsHumansMaleOrgans at RiskRadiotherapy DosageRadiotherapy, Intensity-Modulateddeformationdelivered dosedose accumulationethosOARTonline adaptiveradiotherapy

Identifiers

PMID40657674
PMCPMC12257352

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.