ArticleJournal of sleep research2026
Exploring the Relationship Between Caffeine Consumption, Caffeine Metabolism, and Sleep Behaviours: A Mendelian Randomisation Study.
Article in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Coffee consumption patterns and sleep quality among Saudi Youth: A cross-sectional study.Sleep medicine: X · 2026Article
- Psychobiological Correlates of Perceived Physical Activity Barriers: Insomnia, Chronotype, and Caffeine Consumption.International journal of environmental research and public health · 2026Article
- Exploring the Relationship Between Caffeine Consumption, Caffeine Metabolism, and Sleep Behaviours: A Mendelian Randomisation Study.Journal of sleep research · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Higher consumption of caffeinated beverages is associated with disturbed sleep patterns. Using genetic variants as proxies for caffeine consumption, caffeine metabolism, and sleep traits, we investigated whether this association reflects a direct effect of caffeine. Genetic variants associated with caffeine consumption (n = 407,072), caffeine metabolism (n = 9876), chronotype (n = 449,734), daytime napping (n = 452,633), daytime sleepiness (n = 452,071), getting up in morning (n = 385,949), insomnia (n = 453,379), and sleep duration (n = 446,118) identified in individuals from several studies, including the UK Biobank, were used to explore bi-directional causal relationships between caffeine and sleep using a series of univariable Mendelian Randomisation analyses. We used multivariable Mendelian Randomisation to explore the direct effects of caffeine consumption on sleep behaviours while adjusting for metabolism and vice versa. Higher consumption decreased daytime sleepiness (β
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Registered trials
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