Evidence map›Paper›PMID 40657548›Full record

ArticleJournal of pain research2025

A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity.

Dan Tong, Xinyue Zhang, Zhiyong Xiao, Supattra Taothong, Prapawee Teeravarunyou, Wanxia Wu, Sai Wu, Nuo Chen, Siyuan Tao, Jun Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Dan Tong *Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Xinyue Zhang *Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Zhiyong Xiao *Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Supattra TaothongAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Prapawee TeeravarunyouAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Wanxia WuAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Sai WuAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Nuo ChenAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Siyuan TaoAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Jun ZhouAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Qian SongNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, Tianjin, People's Republic of China.
Fanrong LiangAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.ORCID 0000-0001-8518-9268
Zhengjie LiAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.ORCID 0000-0003-1213-0382
International Headache Genetics Consortium (IHGC)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aims to investigate the potential causal relationship between migraine and white matter (WM) structural connectivity using genetic data and the Mendelian randomization (MR) analyses method. Methods: Genome-wide association study (GWAS) summary statistics for migraine (48,975 cases/540,381 controls) and 206 WM structural connectivity related imaging-derived phenotypes (IDPs) (26,333 samples) were collected. Based on instrumental variables (IVs) selected from the GWAS summary statistics, the bidirectional two-sample MR analyses were conducted to infer bidirectional causal associations between migraine and WM structural connectivity. The inverse variance-weighted (IVW) method served as the primary approach for analyzing causality. Results: In the forward MR analysis, it was found that migraine had a significant effect on right hemisphere somatomotor network to amygdala WM structural connectivity (IVW-derived Conclusion: This study provides genetic evidences for a causal relationship between migraine and WM structural connectivity. These findings provide new perspectives for the understanding of neuropathology and symptomatology in migraine and might provide a potential therapeutic target for future migraine treatment research.

Indexed as

causal relationshipimaging-derived phenotypeMendelian randomizationmigraineneuroimagingwhite matter structure connectivity

Identifiers

PMID40657548
PMCPMC12256053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.