Evidence map›Paper›PMID 40657524›Full record

ArticleIEEE journal of translational engineering in health and medicine2025

Detection of Chronic Musculoskeletal Pain Using Voice Characteristics.

Masakazu Higuchi, Toshiko Iidaka, Chiaki Horii, Gaku Tanegashima, Hiroyuki Oka, Hiroshi Hashizume, Hiroshi Yamada, Munehito Yoshida, Sakae Tanaka, Noriko Yoshimura and 2 more

Abstract read
In one paragraph

Article in IEEE journal of translational engineering in health and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Masakazu HiguchiDepartment of BioengineeringGraduate School of EngineeringThe University of Tokyo Tokyo 113-8656 Japan.ORCID 0000-0003-0329-1141
Toshiko IidakaDepartment of Preventive Medicine for Locomotive Organ Disorders22nd Century Medical and Research CenterThe University of Tokyo Tokyo 113-8655 Japan.ORCID 0009-0007-4662-4248
Chiaki HoriiDepartment of Orthopaedic Surgery, Sensory and Motor System MedicineGraduate School of MedicineThe University of Tokyo Tokyo 113-8655 Japan.
Gaku TanegashimaDepartment of Orthopaedic Surgery, Sensory and Motor System MedicineGraduate School of MedicineThe University of Tokyo Tokyo 113-8655 Japan.
Hiroyuki OkaDepartment of Medical Research and Management for Musculoskeletal Pain22nd Century Medical and Research CenterThe University of Tokyo Tokyo 113-8655 Japan.ORCID 0000-0001-5674-4875
Hiroshi HashizumeDepartment of Orthopedic SurgeryWakayama Medical University School of Medicine Wakayama 641-8509 Japan.ORCID 0000-0002-9064-0284
Hiroshi YamadaDepartment of Orthopedic SurgeryWakayama Medical University School of Medicine Wakayama 641-8509 Japan.ORCID 0000-0002-7694-883X
Munehito YoshidaDepartment of Orthopedic SurgeryWakayama Medical University School of Medicine Wakayama 641-8509 Japan.
Sakae TanakaDepartment of Orthopaedic Surgery, Sensory and Motor System MedicineGraduate School of MedicineThe University of Tokyo Tokyo 113-8655 Japan.ORCID 0000-0001-9210-9414
Noriko YoshimuraDepartment of Preventive Medicine for Locomotive Organ Disorders22nd Century Medical and Research CenterThe University of Tokyo Tokyo 113-8655 Japan.ORCID 0000-0001-9206-4658
Mitsuteru NakamuraGraduate School of Health InnovationKanagawa University of Human Services Kawasaki 210-0821 Japan.ORCID 0000-0002-5851-5424
Shinichi TokunoDepartment of BioengineeringGraduate School of EngineeringThe University of Tokyo Tokyo 113-8656 Japan.ORCID 0000-0002-2691-6979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical pain, particularly musculoskeletal pain, negatively impacts the activities of daily life and quality of life of elderly people. Because pain is a subjective sensation and there are no standard assessment procedures to detect pain, we attempted to quantitatively determine the actual state of chronic pain caused by musculoskeletal organs and related factors based on questionnaires. First, we studied techniques for diagnosing diseases by monitoring the involuntary characteristics of the voice. Then, we applied the technique based on voice characteristics and proposed a voice index to detect chronic musculoskeletal pain. The voice index was derived based on the assumption that physiological changes due to chronic musculoskeletal pain also affect the vocal cords. Subjects in this study were adults, 65 years of age or older, with chronic pain in the musculoskeletal system (lumbar and/or knees). A large-scale population-based cohort study was conducted in 2019. Voice characteristics were extracted from the recorded voices of the subjects, and the characteristics with similar properties were organized into several principal components using principal component analysis. The principal components were further combined using logistic regression analysis to propose a voice index that discriminates between normal subjects and subjects suffering from chronic musculoskeletal pain. A discrimination accuracy of approximately 80% was obtained using the dataset corresponding to the participants with knee pain only, and a discrimination accuracy of approximately 70% was obtained during cross-validation of the same dataset. The proposed voice index may serve as a novel tool for detecting chronic musculoskeletal pain. Clinical impact: The voice-based pain detection holds clinical significance owing to its noninvasive nature, ease of administration, and potential to efficiently assess large populations within a short time frame.

Indexed as

Chronic PainMusculoskeletal PainSignal Processing, Computer-AssistedVoiceAgedAged, 80 and overFemaleHumansMalePrincipal Component AnalysisChronic musculoskeletal painlogistic regression analysisvoice characteristics

Identifiers

PMID40657524
PMCPMC12250996

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.