Evidence map›Paper›PMID 40657484›Full record

ArticleAdvanced functional materials2025

Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane.

Einollah Sarikhani, Vrund Patel, Zhi Li, Dhivya Pushpa Meganathan, Keivan Rahmani, Leah Sadr, Ryan Hosseini, Diether Visda, Shivani Shukla, Hamed Naghsh-Nilchi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. How Neuromorphic Microstructures Control In Vitro Early-Stage Neuronal Outgrowth.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Einollah SarikhaniAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Vrund PatelAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Zhi LiShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Dhivya Pushpa MeganathanAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Keivan RahmaniAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Leah SadrAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Ryan HosseiniAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Diether VisdaAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Shivani ShuklaShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Hamed Naghsh-NilchiAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Adarsh BalajiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Gillian McMahonDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Shaoming ChenAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Johannes SchönebergDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Colleen A McHughDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Lingyan ShiShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.
Zeinab JahedAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, CA 92093, USA.

Funding

Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
Sugar Probed SRS Volumetric imaging of Metabolic ActivitiesR01GM149976 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Lingyan Shi · 2023 to 2026
$1.6M
Mechanisms of large non-coding RNA regulation of gene expressionR00GM120494 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCHUGH, COLLEEN ADARE · 2018 to 2020
$747k
Novel Optical Imaging Approach to Study Neurovascular Coupling SystemR21NS125395 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHI, LINGYAN · 2022 to 2022
$435k
NIBIB NIH HHS T32 EB009380NIGMS NIH HHS R00 GM120494NIGMS NIH HHS R01 GM149976NINDS NIH HHS R21 NS125395
6 · The paper itself

Abstract

Materials with engineered nano-scale surface topographies, such as nanopillars, nanoneedles, and nanowires, mimic natural structures like viral spike proteins, enabling them to bypass biological barriers like the plasma membrane. These properties have led to applications in nanoelectronics for intracellular sensing and drug delivery platforms, some of which are already in clinical trials. Here, evidence is present that nanotopographic materials can induce transient openings in the nuclear membranes of various cell types without penetrating the cells, breaching the nucleo-cytoplasmic barrier, and allowing uncontrolled molecular exchange across the nuclear membrane. These openings, induced by nanoscale curvature, are temporary and repaired through the Endosomal Sorting Complexes Required for Transport (ESCRT)-mediated mechanisms. The findings suggest a potential for nano\topographic materials to temporarily breach the nuclear membrane with potential applications in direct nuclear sensing and delivery.

Indexed as

nanopillarnanotopographynuclear deliverynuclear envelope repairnuclear envelope rupturenuclear mechanicsnuclear mechanotransduction

Identifiers

PMID40657484
PMCPMC12246998

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.