ArticleJournal of Taibah University Medical Sciences2025
Association of ALDH3A1 expression with tumor differentiation, pathological stage, and nodal status in oral squamous cell carcinoma.
Article in Journal of Taibah University Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Review
- Glycation of Salivary Aldehyde Dehydrogenase: Emerging Molecular Mechanisms and Clinical Implications in Oral Disease.Life (Basel, Switzerland) · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To observe the association between Aldehyde dehydrogenase 3 family member A1 (ALDH3A1) levels with histological grade, pathological stage and nodal status in Oral Squamous Cell Carcinoma (OSCC). Methods: A total of 114 diagnosed OSCC patients who underwent Excisional biopsy with complete neck dissection were recruited in the study in accordance with inclusion criteria. H & E slides were assessed for evaluation of clinicopathological features. Immunohistochemical (IHC) staining method was used to study the expression of ALDH3A1. Statistical analysis was performed using SPSS version 21.0. The chi-square test and Fisher exact test were applied to evaluate the association of ALDH3A1 expression with histological grade, nodal metastasis and pathological tumor stage (pT). All tests were two-sided and a Results: This study looked at 114 OSCC patients, most of them were men (76.3 %) with a mean age of 47. The common tumor sites were buccal mucosa (53.5 %) and left side predominance of face (52.6 %). The grades were well (30.7 %), moderate (38.6 %), and 3 poorly differentiated (30.7 %). The expression of ALDH3A1 is significantly strong in the well differentiated compared to the poorly differentiated OSCC ( Conclusions: The decrease in expression of ALDH3A1 in a poorly differentiated and advanced stage OSCC compared to its well differentiated and early stage highlights the potential role of this biomarker as an important prognostic tool.
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