Evidence map›Paper›PMID 40657383›Full record

ArticleInternational journal of medical sciences2025

CircRNA Sequencing Analysis Reveals the Regulatory Role of circ_CDR1as in Penile Squamous Cell Carcinoma via the ceRNA Network.

Lin Du, Shanshan Lv, Zhenzhen Jiang, Xiaohong Song, Leping Liu, Rong Huang, Xinmin Nie, Rong Gui, Jian Li, Junhua Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lin DuDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Shanshan LvDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Zhenzhen JiangDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Xiaohong SongDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Leping LiuDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Rong HuangDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Xinmin NieDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Rong GuiDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Jian LiDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Junhua ZhangDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Jie GuoChina National Clinical Research Center for Geriatric Disorders, National Institution of Drug Clinical Trial, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Jian CaoDepartment of Urology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, China.
Zhizhong LiuDepartment of Urology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, China.
Zhaojian GongDepartment of Oral and Maxillofacial Surgery, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Yanwei LuoDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Penile squamous cell carcinoma (PSCC) is a malignant reproductive tumor, and circRNAs are essential regulators in the progression of cancers. However, their specific roles in PSCC have not been adequately investigated, which are available to function via the competing endogenous RNA (ceRNA) network. We collected 5 normal and 6 PSCC tissue samples for bulk RNA sequencing and obtained differentially expressed circRNAs (DE-circRNAs) and differentially expressed mRNAs (DE-mRNAs). Then we conducted a correlation analysis between them, followed by the prediction and intersection of their target miRNAs and mRNAs by online databases. We constructed a ceRNA network of 11 circRNAs, 14 miRNAs, and 33 mRNAs. The enrichment analysis showed that the positively circRNA-related mRNAs are mainly involved in the positive regulation of leukocyte activation and cell adhesion. It was revealed that circ_CDR1as and its target gene GATA6 were significantly downregulated in PSCC, and their reduction in tumor samples was validated by an external dataset and qRT-PCR, indicating a potential regulatory relationship between them. Our study identified that circ_CDR1as may affect PSCC progression through the circRNA-miRNA-mRNA network, and GATA6 could be one of its possible targets for PSCC therapy strategies.

Indexed as

Carcinoma, Squamous CellPenile NeoplasmsRNA, CircularBiomarkers, TumorGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMaleMicroRNAsRNA, Competitive EndogenousRNA, MessengerSequence Analysis, RNABiomarkers, TumorMicroRNAsRNA, CircularRNA, Competitive EndogenousRNA, MessengerceRNA networkcirc_CDR1ascircRNAGATA6penile squamous cell carcinoma

Identifiers

PMID40657383
PMCPMC12243860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.