Evidence map›Paper›PMID 40657351›Full record

ArticleJournal of mood and anxiety disorders2025

What is latent about trauma exposure? Commentary on the use of latent class analysis for identifying trauma subtypes.

Erika J Wolf, Mark W Miller

Abstract read
In one paragraph

Article in Journal of mood and anxiety disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erika J WolfNational Center for PTSD at VA Boston Healthcare System, Boston, MA, USA.
Mark W MillerNational Center for PTSD at VA Boston Healthcare System, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Latent class analysis (LCA) is a "person-centered" analytic method designed to identify subgroups of individuals defined by a common characteristic that distinguishes them from other groups within a larger population. Many recent studies have applied LCA to data from self-report trauma exposure measures in an effort to identify clinically useful and/or nosologically informative trauma history "types." In this article, we provide a non-technical overview of this analytic approach and its application to trauma exposure data. We raise concerns about the use of LCA for identifying trauma exposure types relating to: (a) the application of a person-centered approach to variables that reflect environmental exposures; (b) lack of evidence that use of LCA is more informative than other more straightforward and generalizable methods for quantifying trauma exposure; (c) failure to show meaningful differences in the correlates (e.g., risk factors, outcomes, treatment response) of latent classes; (d) forcing severity-based categories on variables that are dimensional, promotion of small classes, and misinterpretation of fit statistics; and (e) interpretation of changing class definitions over time as individual-level changes. Collectively, these concerns lead us to ask, "what is latent about trauma exposure?" and suggest the need for alternative approaches to quantifying and summarizing trauma exposure.

Indexed as

Latent class analysisLatent profile analysisPTSDStatistical methodsSubtypeTrauma

Identifiers

PMID40657351
PMCPMC12244057

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.