Evidence map›Paper›PMID 40657316›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Evaluating Modes of Influenza Transmission (EMIT-2): Insights from a Controlled Human Influenza Virus Infection Transmission Trial (CHIVITT).

Jianyu Lai, Hamed Sobhani, Kristen K Coleman, S-H Sheldon Tai, Filbert Hong, Isabel Sierra Maldonado, Yi Esparza, Kathleen M McPhaul, Shengwei Zhu, Don L DeVoe and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Jianyu LaiDepartment of Global, Environmental, and Occupational Health, School of Public Health, University of Maryland, College Park, MD, USA.ORCID 0000-0001-5705-0138
Hamed SobhaniDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Kristen K ColemanDepartment of Global, Environmental, and Occupational Health, School of Public Health, University of Maryland, College Park, MD, USA.
S-H Sheldon TaiDepartment of Global, Environmental, and Occupational Health, School of Public Health, University of Maryland, College Park, MD, USA.
Filbert HongDepartment of Global, Environmental, and Occupational Health, School of Public Health, University of Maryland, College Park, MD, USA.
Isabel Sierra MaldonadoDepartment of Global, Environmental, and Occupational Health, School of Public Health, University of Maryland, College Park, MD, USA.
Yi EsparzaDepartment of Global, Environmental, and Occupational Health, School of Public Health, University of Maryland, College Park, MD, USA.
Kathleen M McPhaulDepartment of Global, Environmental, and Occupational Health, School of Public Health, University of Maryland, College Park, MD, USA.
Shengwei ZhuDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Don L DeVoeDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Justin R OrtizCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-3138-5965
Shuo ChenDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Temima YellinDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Juan Manuel CarrenoDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Benjamin J CowlingSchool of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0002-6297-7154
Aubree GordonSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9352-7877
Wilbur H ChenCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7741-5536
Jelena SrebricDepartment of Mechanical Engineering, University of Maryland, College Park, MD, USA.
Donald K MiltonDepartment of Global, Environmental, and Occupational Health, School of Public Health, University of Maryland, College Park, MD, USA.ORCID 0000-0002-0550-7834

Funding

Evaluating Modes of Influenza Transmission using a Randomized Controlled Trial (EMIT-2-RCT)U19AI162130 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI SREBRIC, JELENA · 2021 to 2025
$15.2M
NIAID NIH HHS U19 AI162130
6 · The paper itself

Abstract

A previous controlled human influenza transmission trial produced minimal transmission using nasal inoculation of an egg adapted virus. Therefore, we implemented a new trial with naturally infected Donors. We recruited healthy Recipients for four, two-week hotel quarantine cohorts and naturally infected, qRT-PCR confirmed Donors for two cohorts. Five Donors (mean age: 21; 80% female; two H1N1, three H3N2, one for cohort 24b and 4 for 24c, Jan-Feb 2024) exposed Recipients (mean age: 36; 55% female, eight in cohort 24b and 3 in 24c) in a hotel room with limited ventilation but a high air recirculation rate. We collected exhaled breath, ambient and personal bioaerosols, fomite swabs, and sera, and analyzed samples using dPCR and fluorescent focus assays, hemagglutination inhibition (HAI) assay, and enzyme-linked immunosorbent assay (ELISA). Compared with previously studied community-acquired influenza cases, we detected viral RNA (44%) and culturable virus (6%) less frequently and measured fewer viral RNA copies (79 - 8.9×10

Identifiers

PMID40657316
PMCPMC12248172

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.