Can Intermittent Teriparatide Facilitate Supraphysiological-Rate Distraction Osteogenesis? A Feasibility Study in the Rabbit Tibial Lengthening Model.

Siddhartha Sharma, John Khing, Navin Kumar, Ram Naresh, Pravir Sihota, Mandeep S Dhillon, Sameer Aggarwal, Pebam Sudesh

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Article in Indian journal of orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Siddhartha SharmaDepartment of Orthopaedics, PGIMER, Chandigarh, India.ORCID 0000-0002-5145-2600

John KhingDepartment of Orthopaedics, PGIMER, Chandigarh, India.

Navin KumarDepartment of Mechanical Engineering, Indian Institute of Technology, Ropar, India.

Ram NareshDepartment of Mechanical Engineering, Indian Institute of Technology, Ropar, India.

Pravir SihotaDepartment of Mechanical Engineering, Indian Institute of Technology, Ropar, India.

Mandeep S DhillonDepartment of Orthopaedics, Fortis Hospital, Mohali, India.

Sameer AggarwalDepartment of Orthopaedics, PGIMER, Chandigarh, India.

Pebam SudeshDepartment of Orthopaedics, PGIMER, Chandigarh, India.

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6 · The paper itself

Abstract

Background: Intermittent teriparatide administration is known to accelerate and promote bone healing. We wanted to investigate if intermittent teriparatide administration could facilitate supraphysiological-rate distraction osteogenesis (DO) in the rabbit tibial lengthening model without compromising on the regenerate quality. Methods: 24 New Zealand white rabbits underwent tibial lengthening of 10 mm by distraction osteogenesis and were divided into two groups. Group A ( Results: There was one mortality in each group. Failure of distraction osteogenesis was noted in one animal in groups A1, A2 and B1, and four animals in Group B2. Kaplan-Meir survival analysis revealed significantly higher failures in Group B2 (log-rank test Conclusion: This feasibility study provides proof of concept of using teriparatide to accelerate distraction osteogenesis to supraphysiological levels, without compromising on the regenerate quality.

Indexed as

Animal modelDistraction osteogenesisLimb lengtheningPTHRabbitRecombinant human parathyroid hormoneTeriparatideTibial lengthening

Identifiers

PMID40657227

DOI10.1007/s43465-025-01420-7

PMCPMC12254107

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