Evidence map›Paper›PMID 40657196›Full record

ReviewSmall science2025

Biodegradable Piezoelectric Micro- and Nanomaterials for Regenerative Medicine, Targeted Therapy, and Microrobotics.

Lorenzo Vannozzi, Carlotta Pucci, Diego Trucco, Claudia Turini, Semih Sevim, Salvador Pané, Leonardo Ricotti

Abstract readReview
In one paragraph

Review in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lorenzo VannozziThe BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà 33 56127 Pisa Italy.ORCID https://orcid.org/0000-0003-3525-5073
Carlotta PucciThe BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà 33 56127 Pisa Italy.
Diego TruccoThe BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà 33 56127 Pisa Italy.
Claudia TuriniThe BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà 33 56127 Pisa Italy.
Semih SevimMulti-Scale Robotics Lab (MSRL) Institute of Robotics and Intelligent Systems (IRIS) ETH Zurich 8092 Zurich Switzerland.
Salvador PanéMulti-Scale Robotics Lab (MSRL) Institute of Robotics and Intelligent Systems (IRIS) ETH Zurich 8092 Zurich Switzerland.
Leonardo RicottiThe BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà 33 56127 Pisa Italy.ORCID https://orcid.org/0000-0001-8797-3742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Piezoelectric micro- and nanomaterials can generate local electrical signals when subjected to mechanical stress, a phenomenon that can be exploited to trigger beneficial effects at the cell and tissue level. In recent years, research on biodegradable piezoelectric material has gained momentum, as these materials can degrade after fulfilling their function. Thus, they promise to considerably impact regenerative medicine, targeted therapy, and microrobotics, with better chances to match regulatory requirements with respect to their nondegradable counterparts. This review offers a comprehensive overview of recent advancements in biodegradable piezoelectric micro- and nanomaterials, focusing on their piezoelectric mechanisms, material types, and methods to enhance their properties. Current characterization techniques, emphasizing both piezoelectricity and biodegradability at the micro/nano scale, are also discussed. Furthermore, it is discussed how to use these materials in intelligent platforms for regenerative medicine and responsive drug delivery systems. The application of piezoelectric micro- and nanomaterials in microrobotics is also examined, particularly their potential for minimally invasive procedures. Finally, challenges and future directions are highlighted, underscoring the importance of biodegradable piezoelectric materials as versatile platforms for advancing biomedical technologies.

Indexed as

biodegradationminimally invasive therapynanorobotsorganic nanomaterialspiezoelectricityregenerative medicine

Identifiers

PMID40657196
PMCPMC12245126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.