Evidence map›Paper›PMID 40657185›Full record

ReviewSmall science2025

MXene-Integrated Composites for Biomedical Applications: Synthesis, Cancer Diagnosis, and Emerging Frontiers.

Aryan Saxena, Akshayat Tyagi, Sushipra Vats, Ishita Gupta, Akhil Gupta, Raminder Kaur, Saurabh Kr Tiwary, Ahmed A Elzatahry, Maninderjeet Singh, Alamgir Karim

Abstract readReview
In one paragraph

Review in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Chelation Drives Surface Substitution in Hybrid-MXenes.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Review
  5. Article
  6. NbAdvanced healthcare materials · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aryan SaxenaDepartment of Applied Chemistry Delhi Technological University Delhi 110042 India.
Akshayat TyagiDepartment of Applied Chemistry Delhi Technological University Delhi 110042 India.
Sushipra VatsDepartment of Chemical and Biomolecular Engineering (Materials Science and Engineering Program) University of Houston TX 77204 USA.
Ishita GuptaDepartment of Applied Chemistry Delhi Technological University Delhi 110042 India.
Akhil GuptaDepartment of Applied Chemistry Delhi Technological University Delhi 110042 India.
Raminder KaurDepartment of Applied Chemistry Delhi Technological University Delhi 110042 India.
Saurabh Kr TiwaryDepartment of Chemical and Biomolecular Engineering University of Houston TX 77204 USA.
Ahmed A ElzatahryDepartment of Chemical and Biomolecular Engineering University of Houston TX 77204 USA.
Maninderjeet SinghDepartment of Chemical and Biomolecular Engineering University of Houston TX 77204 USA.ORCID https://orcid.org/0000-0001-8891-8454
Alamgir KarimDepartment of Chemical and Biomolecular Engineering University of Houston TX 77204 USA.ORCID https://orcid.org/0000-0003-1302-9374

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MXenes, a novel class of two-dimensional (2D) transition metal carbides, carbonitrides, and nitrides, have gained significant attention in biomedicine. They are synthesized via two main approaches: top-down etching of MAX (here, M represents an early transition metal, A represents an element belonging to the A-group, and X represents N or C) phase precursors and bottom-up chemical reduction of metal oxides. While the MAX phase method requires high temperatures, influencing morphology and posing safety concerns, alternative non-MAX synthesis routes are emerging. Due to their unique physical and chemical properties, MXene-based composites hold great promise in regenerative medicine, biosensing, and cancer therapy. However, challenges related to their stability, controlled drug release, and biodegradability remain. This review explores advancements in MXene synthesis, emphasizing non-MAX phase fabrication and biomedical applications. Notably, MXene-based composites have shown remarkable potential in cancer treatment, particularly in photothermal and photodynamic therapy. Their mechanisms, advantages, and limitations are discussed, along with future prospects and challenges in clinical translation. The development of MXene composites offers new avenues for innovative cancer therapies, paving the way for improved treatment strategies.

Indexed as

2D materialsbiodegradabilitycancer therapydrugsMXene synthesisphotoacoustic imaging photothermal therapy and photodynamic therapy

Identifiers

PMID40657185
PMCPMC12245019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.