Evidence map›Paper›PMID 40657169›Full record

ArticleJournal of plastic and reconstructive surgery2025

Botulinum Toxin A Therapy for Glabellar Lines Improves Emotional States: Evaluation of 47 Cases without Mental Disorders.

Hiromi Hanayama, Jun Tada, Hiroto Terashi

Abstract read
In one paragraph

Article in Journal of plastic and reconstructive surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hiromi HanayamaDepartment of Plastic and Aesthetic Surgery, Kobe Hokuto Hospital, Kobe, Japan.
Jun TadaDepartment of Plastic and Aesthetic Surgery, Kobe Hokuto Hospital, Kobe, Japan.
Hiroto TerashiDepartment of Plastic Surgery and Aesthetic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Facial wrinkle treatment using botulinum toxin A (BT-A) is an extremely popular aesthetic procedure. Many studies have been conducted on the improvement of the mental states of depressive patients whose glabellar lines were treated with BT-A. It could be caused by afferent effects derived from the proprioception of related facial muscles, which is known as facial feedback hypothesis. This study highlights the impact of BT-A injections into the glabellar region on the emotional states of participants who have specifically no mental disorders. Methods: A total of 47 Asian participants (42 women and 5 men) without mental disorders completed the Japanese version of the Brief, Momentary Mood Checklist (BMC-J) before and 2 weeks after receiving the treatment for glabellar lines with BT- A injections. Results: Based on BMC-J scores reported by the participants, their emotional states statistically improved after treatment ( Conclusions: To our knowledge, this is the first study of the statistically significant effect of the BT-A treatment on the emotional state of subjects without mental disorders. The experiences of emotions derived from the motions of the frown muscles, which may be caused by the modulation of the amygdala activity, are not so complicated but extremely primitive, such as pleasure and unpleasure. This might be the reason why our results of BMC-J, which is used to measure basic emotions, indicated more clearly that negative emotions reduced compared with positive ones, in contrast to the finding of previous published reports that measured more complicated emotions such as feelings.

Indexed as

amygdalabotulinum toxin Aemotional statefacial feedback hypothesisfrown muscles

Identifiers

PMID40657169
PMCPMC12240690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.