ArticleOpen forum infectious diseases2025
HIV Care Continuum Outcomes Among Adolescents and Young Adults Living With HIV in Latin America and the Caribbean: Association With Depression and Substance Use.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The Caribbean, Central and South America Network for HIV Epidemiology: 20 Years of HIV Research in the Region.Journal of the International AIDS Society · 2026Article
- Multifactorial determinants of lost to follow-up in antiretroviral therapy: evidence from a case-control study in Mexico.AIDS research and therapy · 2026Article
- Analysis of Adolescent HIV Care Cascade Outcomes in PEPFAR-Supported Programs in Central America, October 2020-September 2024.Tropical medicine and infectious disease · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Background: Adolescents and young adults with HIV (AYAWH) represent vulnerable populations, with increased risk of virologic failure, loss to follow-up, and death. Depression and substance use in AYAWH can lead to worse outcomes, yet this overlap is not well understood. Methods: This cross-sectional study included adolescents (10-17 years) and young adults (18-24 years) with HIV in the Caribbean, Central and South America network for HIV epidemiology (CCASAnet). Participants were administered surveys to assess for depression, substance use, and antiretroviral therapy (ART) adherence. Risk factors for depression; alcohol, tobacco, and substance use; missing ART doses; viral suppression; and 1-year retention were assessed. Results: Six hundred twenty-five AYAWH were included. Depression prevelance was 16%. Males (adjusted odds ratio [aOR], 0.26; 95% CI, 0.16-0.44) and younger youth (15-year-olds vs 18-year-olds: aOR, 0.61; 95% CI, 0.40-0.95) were less likely to have depression. Fifty-eight percent reported using alcohol, 28% reported tobacco use, 17% reported cannabis use, and 4% reported cocaine use. Forty-one percent missed 1 or more doses of ART in the past week. Forty percent had detectable viral loads at the time of survey completion. Those who acquired HIV perinatally were more likely to have an unsuppressed viral load (aOR, 2.4; 95% CI, 1.24-4.62; Conclusions: Substance use and depression were prevalent in AYAWH, as were missed doses of ART and detectable viral loads.
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