Evidence map›Paper›PMID 40657165›Full record

ArticleOpen forum infectious diseases2025

Viral Etiologies of Acute Respiratory Illness in Older Adults and of Congestive Heart Failure and Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization During 2 Prepandemic Respiratory Seasons.

Chris Choi, Gabriella Ess, Ashley Tippett, Luis Salazar, Elizabeth Grace Taylor, Caroline Ciric, Olivia Reese, Andrew Cheng, Theda Gibson, Wensheng Li and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Chris ChoiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0003-9002-7484
Gabriella EssDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Ashley TippettDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Luis SalazarDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-5454-5741
Elizabeth Grace TaylorDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0000-2453-8137
Caroline CiricDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Olivia ReeseDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Andrew ChengDepartment of Medicine, Hope Clinic, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-2201-8052
Theda GibsonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Wensheng LiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Hui-Mien HsiaoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Kieffer HellmeisterDepartment of Medicine, Hope Clinic, Emory University School of Medicine, Atlanta, Georgia, USA.
Zayna Al-HuseinDepartment of Medicine, Hope Clinic, Emory University School of Medicine, Atlanta, Georgia, USA.
Robin HublerPfizer, Inc. New York, New York, USA.
Elizabeth BegierPfizer, Inc. New York, New York, USA.ORCID https://orcid.org/0000-0002-1287-5416
Qing LiuPfizer, Inc. New York, New York, USA.
Sonal UppalPfizer, Inc. New York, New York, USA.
Warren V KalinaPfizer, Inc. New York, New York, USA.
Bradford GessnerPfizer, Inc. New York, New York, USA.ORCID https://orcid.org/0000-0002-6216-7194
Luis JodarPfizer, Inc. New York, New York, USA.ORCID https://orcid.org/0000-0003-1246-530X
Satoshi KamidaniDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-6829-0700
Carol KaoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Inci YildirimDepartment of Pediatrics, Yale-New Haven Hospital, New Haven, Connecticut, USA.
Larry J AndersonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Nadine RouphaelDepartment of Medicine, Hope Clinic, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-2512-7919
Evan J AndersonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Christina A RostadDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-8439-0592

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In adults, the infectious etiologies of acute respiratory illnesses (ARIs) and of exacerbations of cardiopulmonary diseases requiring hospitalization are incompletely understood. Methods: We conducted a prospective surveillance study of older adults hospitalized with acute respiratory illness (ARI) and adults of any age hospitalized with exacerbations of congestive heart failure (CHF) or chronic obstructive pulmonary disease (COPD) at 2 urban hospitals in Atlanta, Georgia, during the 2018-2019 and 2019-2020 respiratory seasons along with contemporaneous healthy controls. All participants had nasopharyngeal and oropharyngeal swabs collected and tested for common viral and bacterial etiologies using a BioFire multiplexed respiratory panel. A subset of patients had paired serological testing for respiratory syncytial virus (RSV), and standard-of-care microbiologic testing results were included when available. Demographics, clinical characteristics, and outcomes were determined through a combination of participant interview and medical record abstraction for hospitalized participants. Results: A total of 1558 participants were enrolled and included in the analysis. Overall, 757 participants (48.6%) were hospitalized for ARI, 490 (31.5%) for CHF exacerbation, and 311 (20.0%) for COPD exacerbation. At least 1 pathogen was detected in 476 (30.6%) participants, most commonly rhinovirus/enterovirus (127/1558 [8.2%]), influenza (119/1558 [7.6%]), and RSV (92/1558 [5.9%]). Although bacterial and fungal infections were uncommon, these were associated with severe clinical outcomes, including duration of hospitalization and mechanical ventilation. Conclusions: Respiratory viruses contributed substantially to hospitalization for ARI and cardiopulmonary exacerbations among our cohort of high-risk adults, underscoring the need for effective therapeutic and preventive interventions in this vulnerable population.

Indexed as

enterovirusHMPVinfluenzarhinovirusRSV

Identifiers

PMID40657165
PMCPMC12247161

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.